印度三级糖尿病护理中心对 2 型糖尿病患者缺铁性贫血的发病率的调查。

Frequency of iron deficiency anemia in type 2 diabetes - Insights from tertiary diabetes care centres across India.

机构信息

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, ICMR Centre for Advanced Research on Diabetes, Chennai, India.

Emcure Pharmaceuticals Ltd., Pune, India.

出版信息

Diabetes Metab Syndr. 2022 Nov;16(11):102632. doi: 10.1016/j.dsx.2022.102632. Epub 2022 Sep 28.

DOI:10.1016/j.dsx.2022.102632

PMID:36343394

Abstract

AIM

To study the frequency of iron deficiency anemia (IDA) in individuals with type 2 diabetes mellitus (T2DM) seen at tertiary diabetes care centres across India.

METHODS

This is a retrospective study (January 1, 2017-December 31, 2019), which included 1137 individuals with T2DM, aged ≥18 years, for whom data on glycemic, lipid and haematological parameters were available. Anthropometric measurements were done using standardized techniques. Biochemical investigations included fasting plasma glucose[FPG], post prandial plasma glucose, HbA1c, lipids and serum ferritin and iron wherever feasible.

RESULTS

Of the 1137 individuals included for the study, 117 (10.3%) were categorized as no 'iron deficiency' (ID) group [normal hemoglobin: male ≥13 g/dl, female ≥12 g/dl and normal serum ferritin ≥70 μg/L], 123 (10.8%) as ID group [normal hemoglobin and low serum ferritin <70 μg/L)], 447 (39.3%) as IDA group [low haemoglobin: male <13 g/dl, female <12 g/dl and low serum ferritin] and 450 (39.6%) as 'anemia of chronic disease' (ACD) group [low hemoglobin and normal serum ferritin]. The percentage of women having ID (57.7%) and IDA (65.3%) was significantly higher than their male counterparts. ID was most prevalent (61.7%) in the individuals with duration of diabetes <5 years whereas ACD was most prevalent (50.5%) in individuals with long standing diabetes (>10 years). Independent risk factors for IDA were female gender (OR 3.3,95% CI:1.75-6.23, p < 0.001), duration of diabetes (OR 1.05, 95% CI 1.01-1.11, p = 0.028) and FPG (OR 1.01, 95% CI 0.99-1.00, p = 0.018).

CONCLUSIONS

There is a need of identifying and monitoring iron status and anemia in patients with T2DM.

摘要

目的

研究在印度各地的三级糖尿病护理中心就诊的 2 型糖尿病（T2DM）患者中铁缺乏性贫血（IDA）的频率。

方法

这是一项回顾性研究（2017 年 1 月 1 日至 2019 年 12 月 31 日），纳入了 1137 名年龄≥18 岁的 T2DM 患者，这些患者有血糖、血脂和血液学参数的数据。采用标准化技术进行人体测量。生化检查包括空腹血糖[FPG]、餐后血糖、HbA1c、血脂和血清铁蛋白和铁，在可行的情况下。

结果

在纳入研究的 1137 名患者中，117 名（10.3%）被归类为无“铁缺乏”（ID）组[正常血红蛋白：男性≥13 g/dl，女性≥12 g/dl，正常血清铁蛋白≥70μg/L]，123 名（10.8%）为 ID 组[正常血红蛋白和低血清铁蛋白<70μg/L]，447 名（39.3%）为 IDA 组[低血红蛋白：男性<13 g/dl，女性<12 g/dl，低血清铁蛋白]和 450 名（39.6%）为“慢性病性贫血”（ACD）组[低血红蛋白和正常血清铁蛋白]。患有 ID（57.7%）和 IDA（65.3%）的女性比例明显高于男性。在糖尿病病程<5 年的患者中，ID 最为常见（61.7%），而在病程较长的患者（>10 年）中，ACD 最为常见（50.5%）。IDA 的独立危险因素是女性（OR 3.3，95%CI：1.75-6.23，p<0.001）、糖尿病病程（OR 1.05，95%CI 1.01-1.11，p=0.028）和 FPG（OR 1.01，95%CI 0.99-1.00，p=0.018）。