一种由两种生物标志物激活的用于多部位成像和基因沉默的DNA-金纳米机器。
A DNA-Au nanomachine activated by dual types of biomarkers for multi-site imaging and gene silencing.
作者信息
Zhou Yanmei, Li Zhaoge, Wu Tian, Ning Juan, Hu Guizhen, Nie Yamin
机构信息
Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
出版信息
Chem Commun (Camb). 2022 Nov 24;58(94):13107-13110. doi: 10.1039/d2cc05017j.
A programmed DNA-Au nanomachine has been constructed to achieve imaging of transmembrane glycoprotein MUC1 and cytoplasmic miRNA-21 and trigger gene silencing therapy. The results of MCF-7 cell-specific imaging and apoptosis experiments demonstrate that the nanomachine provides a valuable nanotheranostic platform for accurate multi-site imaging and intracellular gene silencing.
一种程序化的DNA-金纳米机器已被构建出来，用于实现跨膜糖蛋白MUC1和细胞质微小RNA-21的成像，并触发基因沉默疗法。MCF-7细胞特异性成像和凋亡实验结果表明，该纳米机器为精确的多部位成像和细胞内基因沉默提供了一个有价值的纳米诊疗平台。
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