Tcholakian R K, de la Cruz A, Chowdhury M, Steinberger A, Coy D H, Schally A V
Fertil Steril. 1978 Nov;30(5):600-3.
Nanogram quantities of a luteinizing hormone-releasing hormone (LHRH) agonist, [D-Leu6,des-Gly-NH2(10)]-LHRH ethylamide, were injected into immature male rats twice daily for 40 days. Treatment with the analog significantly increased serum luteinizing hormone and follicle-stimulating hormone levels, but suppressed accessory sex organ weights. Plasma and testicular concentrations of testosterone were also significantly decreased. The agonist did not alter body, pituitary, or testis weights. Spermatogenesis and the morphology or density of the Leydig cells also appeared not to be affected. A possible direct effect of the analog on the testes is discussed.
将纳克量的促黄体生成激素释放激素（LHRH）激动剂[D-亮氨酸6，去甘氨酸-NH2（10）]-LHRH乙酰胺每日两次注射到未成熟雄性大鼠体内，持续40天。用该类似物治疗显著提高了血清促黄体生成激素和促卵泡激素水平，但抑制了附属生殖器官重量。睾酮的血浆和睾丸浓度也显著降低。该激动剂未改变身体、垂体或睾丸重量。精子发生以及莱迪希细胞的形态或密度似乎也未受影响。讨论了该类似物对睾丸可能的直接作用。
