儿童癌症和脑肿瘤幸存者的激素替代疗法：安全性与争议
Hormone replacement in survivors of childhood cancer and brain tumors: safety and controversies.
作者信息
Maa van Roessel Ichelle, Bakker Boudewijn, van Santen Hanneke M, Chemaitilly Wassim
机构信息
Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, AB Utrecht, The Netherlands.
Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands.
出版信息
Endocr Connect. 2022 Dec 13;12(1). doi: 10.1530/EC-22-0382. Print 2023 Jan 1.
Childhood cancer survivors are at risk for developing endocrine disorders, including deficits in growth hormone, thyroid hormone and sex hormones. The influence these hormones have on cell growth and metabolism has raised concerns regarding the safety of their use as treatments in survivors of childhood cancer and brain tumors. This article offers a summary of current knowledge, controversies and areas for future research pertaining to this area.
儿童癌症幸存者有患内分泌失调的风险，包括生长激素、甲状腺激素和性激素缺乏。这些激素对细胞生长和新陈代谢的影响引发了人们对其作为儿童癌症和脑肿瘤幸存者治疗手段安全性的担忧。本文概述了该领域的现有知识、争议以及未来研究方向。
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