Kwak Jimin, Woo Junhyeok, Park Seongmin, Lim Mi Hee
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
J Inorg Biochem. 2023 Jan;238:112053. doi: 10.1016/j.jinorgbio.2022.112053. Epub 2022 Oct 28.
The accumulation of amyloid-β (Aβ) aggregates is found in the brains of Alzheimer's disease patients. Thus, numerous efforts have been made to develop chemical reagents capable of targeting Aβ peptides and controlling their aggregation. In particular, tunable coordination and photophysical properties of transition metal complexes, with variable oxidation and spin states on the metal centers, can be utilized to probe Aβ aggregates and alter their aggregation profiles. In this review, we illustrate some rational strategies for designing photoactivatable metal complexes as chemical sensors for Aβ peptides or modulators against their aggregation pathways, with some examples.
在阿尔茨海默病患者的大脑中发现了β-淀粉样蛋白（Aβ）聚集体的积累。因此，人们已经做出了许多努力来开发能够靶向Aβ肽并控制其聚集的化学试剂。特别是，过渡金属配合物具有可调节的配位和光物理性质，其金属中心具有可变的氧化态和自旋态，可用于探测Aβ聚集体并改变其聚集模式。在这篇综述中，我们举例说明了一些合理的策略，用于设计可光激活的金属配合物作为Aβ肽的化学传感器或针对其聚集途径的调节剂。
