Vettor R, De Palo C, Calò L, De Carlo E, Sicolo N, Martini C, Federspil G
Mol Cell Endocrinol. 1986 Apr;45(1):65-70. doi: 10.1016/0303-7207(86)90083-3.
Many experimental observations show that prolonged physical exercise produces an increase of muscular glucose uptake. Recent findings suggest that the kallikrein-kinin-prostaglandin system may be related to this phenomenon, but so far, no direct evidence of quantitative alteration in this system has been observed during exercise. We measured plasma kallikrein and muscular phospholipase A2 activity, respectively the first and the last steps of reactions leading to prostaglandin synthesis. We demonstrated, for the first time, that during exercise plasma kallikrein activity increases in rats. We also observed an increase of muscular phospholipase A2 activity after exercise and a positive correlation between these parameters. Our findings demonstrate, under physiological conditions of enhanced muscular glucose uptake, a concomitant significant increase of plasma kallikrein and muscular phospholipase A2 activity, supporting the hypothesis that activation of the kallikrein-kinin-prostaglandin system may play some part in the enhanced muscular glucose uptake during physical activity.
许多实验观察表明，长时间的体育锻炼会使肌肉对葡萄糖的摄取增加。最近的研究结果表明，激肽释放酶-激肽-前列腺素系统可能与这一现象有关，但迄今为止，尚未观察到该系统在运动过程中发生定量改变的直接证据。我们分别测量了血浆激肽释放酶和肌肉磷脂酶A2的活性，它们分别是导致前列腺素合成反应的第一步和最后一步。我们首次证明，在运动过程中，大鼠血浆激肽释放酶活性增加。我们还观察到运动后肌肉磷脂酶A2活性增加，且这些参数之间呈正相关。我们的研究结果表明，在肌肉葡萄糖摄取增加的生理条件下，血浆激肽释放酶和肌肉磷脂酶A2活性同时显著增加，支持了激肽释放酶-激肽-前列腺素系统的激活可能在体育活动中增强肌肉葡萄糖摄取中起一定作用的假说。
