Center for Reproductive Medicine, XuZhou Central Hospital, No. 199, Jiefang Road, Xuzhou, 221009, Jiangsu, China.
Department of Obstetrics and Gynecology, XuZhou Central Hospital, No. 199, Jiefang Road, Xuzhou, 221009, Jiangsu, China.
BMC Endocr Disord. 2022 Nov 8;22(1):272. doi: 10.1186/s12902-022-01179-0.
We aimed to evaluate the performance of Chinese visceral adiposity index (CVAI), visceral adiposity index (VAI), lipid accumulation product (LAP), triglyceride glucose (TyG) as indices in screening abnormal glucose tolerance (AGT) in Chinese women with polycystic ovary syndrome (PCOS), using the oral glucose tolerance test (OGTT) as a reference test. In addition, we essentially compared the abilities of these indices with body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG).
All 1113 PCOS patients evaluated in this study underwent OGTTs. The 2-h post-oral glucose load (2 h-PG) level was used to categorize subjects into two groups: those having AGT or normal glucose tolerance (NGT) levels.
A statistically significant positive correlation between levels of 2 h-PG and FPG, BMI, WC, LAP, VAI, CVAI, TyG, (P < 0.05), was observed. The strongest correlation was found between the levels of 2 h-PG and CVAI (r = 0.47). The CVAI provided the highest area under the receiver-operating characteristic curve (AUC) for AGT, followed by LAP, BMI, TyG, VAI, WC, and FPG. The CVAI of 32.61 (with AUC: 0.76, sensitivity: 73%, specificity: 70%, positive preductive value (PPV): 0.41, negative predictive value (NPV): 0.90) was found to be the cut-off point for AGT in Chinese women with PCOS.
CVAI may not reliably detect AGT in Chinese women with PCOS. However, it is suitable as a first screening indicator to guide physicians to ordering OGTT.
我们旨在评估中国内脏脂肪指数（CVAI）、内脏脂肪指数（VAI）、脂积产物（LAP）、甘油三酯葡萄糖（TyG）作为中国多囊卵巢综合征（PCOS）女性异常葡萄糖耐量（AGT）筛查指标的性能，以口服葡萄糖耐量试验（OGTT）作为参考试验。此外，我们还比较了这些指数与体重指数（BMI）、腰围（WC）、空腹血糖（FPG）的能力。
本研究评估的所有 1113 例 PCOS 患者均接受 OGTT 检查。将口服葡萄糖负荷后 2 小时（2h-PG）水平用于将受试者分为两组：AGT 或正常葡萄糖耐量（NGT）水平。
观察到 2h-PG 水平与 FPG、BMI、WC、LAP、VAI、CVAI、TyG 呈显著正相关（P<0.05）。2h-PG 水平与 CVAI 相关性最强（r=0.47）。CVAI 对 AGT 的曲线下面积（AUC）最高，其次是 LAP、BMI、TyG、VAI、WC 和 FPG。CVAI 为 32.61（AUC：0.76，敏感性：73%，特异性：70%，阳性预测值（PPV）：0.41，阴性预测值（NPV）：0.90）被发现是中国 PCOS 女性 AGT 的截断点。
CVAI 可能无法可靠地检测中国 PCOS 女性的 AGT。然而，它适合作为指导医生进行 OGTT 检查的初步筛查指标。
