Wang J N, Wang C, Wang J, Song Y X, He Y P, Lu Z X
Emergency Department, Qingdao Hospital of Traditional Chinese Medicine (Qingdao Hiser Hospital) , Qingdao 266033, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Oct 20;40(10):782-784. doi: 10.3760/cma.j.cn121094-20211027-00520.
Patients with organophosphate poisoning usually die from respiratory depression and respiratory failure. The incidence of rhabdomyolysis is relatively low, but the mortality rate is extremely high once it occurs. In this paper, the treatment of a patient with acute phoxim poisoning was analyzed. The patient developed severe rhabdomyolysis syndrome on the 3rd day of treatment, the creatine kinase exceeded the normal value by more than 300 times (up to 103510.65 U/L) , and renal failure occurred. Clinical treatment included active detoxification, blood purification, organ support, and internal environment maintenance. The patient's rhabdomyolysis continued, and the condition worsened. Finally, the family gave up the treatment and the patient died. It is suggested that attention should be paid to the occurrence of rhabdomyolysis syndrome during the treatment of organophosphorus poisoning, and timely blood purification technology may be the key to treatment.
有机磷中毒患者通常死于呼吸抑制和呼吸衰竭。横纹肌溶解症的发病率相对较低，但一旦发生，死亡率极高。本文分析了1例急性辛硫磷中毒患者的治疗情况。该患者在治疗第3天出现严重横纹肌溶解综合征，肌酸激酶超过正常值300多倍（高达103510.65 U/L），并发生肾衰竭。临床治疗包括积极解毒、血液净化、器官支持及维持内环境稳定。患者横纹肌溶解持续存在，病情恶化。最终，家属放弃治疗，患者死亡。提示在有机磷中毒治疗过程中应注意横纹肌溶解综合征的发生，及时应用血液净化技术可能是治疗的关键。
