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职业与环境暴露与特发性肺纤维化的研究进展

[Research progress of occupational and environmental exposure and idiopathic pulmonary fibrosis].

作者信息

Guo Z Y, Ye Q

机构信息

Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

出版信息

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Oct 20;40(10):790-794. doi: 10.3760/cma.j.cn121094-20210309-00132.

Abstract

Occupational and environmental exposure can directly cause specific lung diseases, and can also induce autoimmune diseases that can lead to various types of interstitial lung diseases. In recent years, it was discovered that certain occupational and environmental exposure was related to the increased risk of Idiopathic pulmonary fibrosis (IPF) disease and progression, including metal and mineral dust, wood dust, organic dust, asbestos dust, silica dust, cigarette smoke and air pollution. IPF is a chronic progressive fibrotic lung disease of unknown etiology, with a characteristic imaging and histologic pattern called usual interstitial pneumonia. This article is a review based on the correlation and mechanism of occupational and environmental exposure in the pathogenesis and disease progression of IPF to improve the understanding of the disease and promote the formulation of treatment plans.

摘要

职业和环境暴露可直接导致特定的肺部疾病,也可诱发自身免疫性疾病,进而引发各种类型的间质性肺病。近年来,人们发现某些职业和环境暴露与特发性肺纤维化(IPF)疾病的风险增加及病情进展有关,包括金属和矿物粉尘、木尘、有机粉尘、石棉尘、硅尘、香烟烟雾和空气污染。IPF是一种病因不明的慢性进行性纤维化肺病,具有一种称为普通间质性肺炎的特征性影像学和组织学模式。本文基于职业和环境暴露在IPF发病机制和疾病进展中的相关性及机制进行综述,以增进对该疾病的认识,并促进治疗方案的制定。

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