Trethewey Samuel P, Walters Gareth I
Respiratory Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham B95SS, UK.
Birmingham Regional NHS Occupational Lung Disease Service, Birmingham Chest Clinic, Birmingham B33HX, UK.
Medicina (Kaunas). 2018 Dec 10;54(6):108. doi: 10.3390/medicina54060108.
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterised by a progressive and irreversible decline in lung function, which is associated with poor long-term survival. The pathogenesis of IPF is incompletely understood. An accumulating body of evidence, obtained over the past three decades, suggests that occupational and environmental exposures may play a role in the development of IPF. This narrative literature review aims to summarise current understanding and the areas of ongoing research into the role of occupational and environmental exposures in the pathogenesis of IPF.
特发性肺纤维化（IPF）是一种慢性间质性肺疾病，其特征是肺功能进行性且不可逆地下降，这与长期生存率低相关。IPF的发病机制尚未完全明确。过去三十年积累的大量证据表明，职业和环境暴露可能在IPF的发生发展中起作用。本叙述性文献综述旨在总结目前对于职业和环境暴露在IPF发病机制中的作用的认识以及正在进行研究的领域。
