一种新型异麦角灵基衍生物对偏头痛的预防性治疗

Preventive treatment of migraine headache with a new isoergolenyl derivative.

作者信息

Herrmann W M, Kristof M, Sastre M, Sastre M

出版信息

J Int Med Res. 1978;6(6):476-82. doi: 10.1177/030006057800600611.

Abstract

In the present double-blind clinical trial an isoergolenyl derivative with periphal antiserotonin, central dopaminergic activity and alpha-increasing effect on the human EEG, lisuride hydrogen maleate, was tested against placebo in a six-month trial involving 240 patients. Lisuride in long-term administration significantly reduces the frequency of migraine attacks in comparison to placebo. Its advantages are good tolerance and minimal side-effects. It is therefore concluded that lisuride is a suitable and effective drug for the prevention of migraine.

摘要

在本次双盲临床试验中，对一种具有外周抗血清素、中枢多巴胺能活性以及对人类脑电图有α波增强作用的异麦角酰衍生物——马来酸麦角苄酯，与安慰剂进行了对比测试。该试验为期六个月，涉及240名患者。与安慰剂相比，长期服用马来酸麦角苄酯可显著降低偏头痛发作的频率。其优点是耐受性良好且副作用极小。因此得出结论，马来酸麦角苄酯是一种适用于预防偏头痛的有效药物。