Leknessund Oda G R, Morelli Vania M, Strand Bjørn Heine, Hansen John-Bjarne, Brækkan Sigrid K
Department of Clinical Medicine, Thrombosis Research Center (TREC) UiT, The Arctic University of Norway Tromso Norway.
Division of Internal Medicine University Hospital of North Norway Tromsø Norway.
Res Pract Thromb Haemost. 2022 Nov 4;6(7):e12833. doi: 10.1002/rth2.12833. eCollection 2022 Oct.
Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE).
We aimed to investigate the association between HGS and risk of incident VTE in a population-based cohort.
Participants ( = 13,704) from the fourth to seventh surveys of the Tromsø study (Tromsø4-Tromsø7, enrollment: 1994-2016) were followed throughout 2020, and all incident VTEs were recorded. HGS of the nondominant hand was measured using a Martin Vigorimeter (Tromsø4-Tromsø6) and a Jamar Digital Dynamometer (Tromsø7). Hazard ratios (HRs) for VTE with 95% confidence intervals (CIs) according to weak HGS (less than 25th percentile) versus normal HGS (25th percentile or greater) were estimated using Cox regression models and adjusted for age, sex, body height, body mass index, physical activity, cardiovascular disease, and cancer.
During a median of 6.5 years of follow-up, 545 incident VTEs occurred. Participants with weak HGS had a 27% higher risk of VTE (HR, 1.27; 95% CI, 1.03-1.57) compared to those with normal HGS. Subgroup analyses revealed that the point estimates were higher for unprovoked VTE (HR, 1.35; 95% CI, 0.96-1.91) and deep vein thrombosis (DVT; HR, 1.52; 95% CI, 1.14-2.01). Similar results were found in analyses restricted to men, women, and elderly (aged greater than 75 years).
A weak HGS was associated with increased risk of VTE, and particularly unprovoked VTE and isolated DVT. Our findings suggest that weak muscle strength may be a risk factor for VTE.
握力（HGS）是全身肌肉力量的常见替代指标，与多种不良健康结局和死亡率相关。然而，关于握力与静脉血栓栓塞症（VTE）风险之间关联的数据有限。
我们旨在调查基于人群的队列中握力与VTE发病风险之间的关联。
对特罗姆瑟研究第四次至第七次调查（特罗姆瑟4 - 特罗姆瑟7，入组时间：1994 - 2016年）的参与者（n = 13704）在2020年全年进行随访，并记录所有VTE发病情况。使用马丁握力计（特罗姆瑟4 - 特罗姆瑟6）和贾马尔数字测力计（特罗姆瑟7）测量非优势手的握力。根据弱握力（低于第25百分位数）与正常握力（第25百分位数及以上），使用Cox回归模型估计VTE的风险比（HR）及其95%置信区间（CI），并对年龄、性别、身高、体重指数、身体活动、心血管疾病和癌症进行校正。
在中位随访6.5年期间，发生了545例VTE发病。与正常握力者相比，弱握力参与者发生VTE的风险高27%（HR，1.27；95% CI，1.03 - 1.57）。亚组分析显示，对于不明原因VTE（HR，1.35；95% CI，0.96 - 1.91）和深静脉血栓形成（DVT；HR，1.52；95% CI，1.14 - 2.01），点估计值更高。在仅限于男性、女性和老年人（年龄大于75岁）的分析中也发现了类似结果。
弱握力与VTE风险增加相关，尤其是不明原因VTE和孤立性DVT。我们的研究结果表明，肌肉力量弱可能是VTE的一个风险因素。
