Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, California, USA.
Department of Medicine, University of California, San Francisco, California, USA.
Annu Rev Pathol. 2023 Jan 24;18:311-335. doi: 10.1146/annurev-pathol-042320-112212. Epub 2022 Nov 9.
Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional program, including expression of taste transduction signaling pathways. Here, we summarize seminal and recent findings on tuft cells, focusing on major categories of function-instigation of type 2 cytokine responses, orchestration of antimicrobial responses, and emerging roles in tissue repair-and describe tuft cell-derived molecules used to affect these functional programs. We review what is known about the development of tuft cells from epithelial progenitors under homeostatic conditions and during disease. Finally, we discuss evidence that immature, or nascent, tuft cells with potential for diverse functions are driven toward dominant effector programs by tissue- or perturbation-specific contextual cues, which may result in heterogeneous mature tuft cell phenotypes both within and between tissues.
Tuft 细胞存在于具有明显干细胞隔室、组织架构和腔暴露的组织中，但它们集中在一个共同的转录程序上，包括味觉转导信号通路的表达。在这里，我们总结了关于 Tuft 细胞的重要发现，重点介绍了 Tuft 细胞的主要功能类别——引发 2 型细胞因子反应、协调抗菌反应，以及在组织修复中的新兴作用，并描述了用于影响这些功能程序的 Tuft 细胞衍生分子。我们回顾了在稳态条件下和疾病过程中上皮祖细胞衍生 Tuft 细胞的发育情况。最后，我们讨论了这样一种证据，即具有多种功能潜力的不成熟或新生的 Tuft 细胞，会被组织或扰动特异性的上下文线索驱动，向优势效应程序发展，这可能导致同一组织或不同组织中成熟 Tuft 细胞表型的异质性。
