Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Mol Biol Rep. 2023 Jan;50(1):883-888. doi: 10.1007/s11033-022-07998-7. Epub 2022 Nov 9.
Vitamin D insufficiency is a global health concern and low vitamin D status is regularly associated with reduced muscle mass and sarcopenia in observational research. Recent research using Mendelian randomization (MR) has highlighted the potentially causal positive effect of serum vitamin D (25(OH)D) on total, trunk and upper body appendicular fat-free mass (FFM). However, no such effect was found in lower body FFM, a result that mirrors the outcomes of some vitamin D intervention studies. Here we review the current literature on vitamin D, muscle mass and strength and discuss some potential mechanisms for the differing effects of vitamin D on upper and lower body FFM. In particular, differences in distribution of the vitamin D receptor as well as androgen receptors, in the upper and lower body musculature, will be discussed.
维生素 D 不足是一个全球性的健康问题，低维生素 D 状态与观察性研究中肌肉量减少和肌肉减少症有关。最近使用孟德尔随机化 (MR) 的研究强调了血清维生素 D (25(OH)D) 对全身、躯干和上肢去脂体重 (FFM) 的潜在因果正效应。然而，在下半身 FFM 中并未发现这种效应，这与一些维生素 D 干预研究的结果一致。在这里，我们回顾了关于维生素 D、肌肉质量和力量的当前文献，并讨论了维生素 D 对上下身 FFM 影响不同的一些潜在机制。特别是，将讨论上半身和下半身肌肉中维生素 D 受体和雄激素受体分布的差异。
