Affective Cognitive Neuroscience Laboratory, Department of Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31-343, Krakow, Poland.
Psychopharmacology (Berl). 2022 Dec;239(12):3975-3984. doi: 10.1007/s00213-022-06273-8. Epub 2022 Nov 9.
In this study, we examined whether trait sensitivity to negative feedback (NF) can interact with the effects of chronic stress and antidepressant treatment on anxiety and stress-induced coping strategies in rats. Results of the conducted experiments indicated that animals displaying trait insensitivity to NF were more prone to develop stress-induced anxiety than their NF-sensitive conspecifics. Moreover, an analysis of the behavioral patterns displayed by the NF-insensitive animals during the forced swim test (FST) revealed complementary (anxiety-driven) effects of trait sensitivity to NF on the strategy of coping with an acute, stressful situation. Finally, an analysis of the interactions between NF sensitivity and the effects of antidepressant drug - mirtazapine - revealed that in animals subjected to chronic stress, the effects of the drug on anxiety and coping strategies differ significantly between animals classified as NF insensitive and NF sensitive. The present results suggest that NF sensitivity screening could be potentially used to determine individual vulnerability to development of affective disorders and effectivity of their treatment.
在这项研究中，我们研究了特质性负反馈敏感性（NF）是否会与慢性应激和抗抑郁治疗对大鼠焦虑和应激诱导应对策略的影响相互作用。实验结果表明，与 NF 敏感的同类动物相比，对 NF 不敏感的动物更容易出现应激诱导的焦虑。此外，对 NF 不敏感动物在强迫游泳试验（FST）中表现出的行为模式进行分析，揭示了 NF 敏感性对急性应激情况应对策略的互补（焦虑驱动）效应。最后，对 NF 敏感性与抗抑郁药物米氮平作用之间的相互作用进行分析，结果表明，在慢性应激的动物中，药物对焦虑和应对策略的影响在被分类为 NF 不敏感和 NF 敏感的动物之间存在显著差异。这些结果表明，NF 敏感性筛选可能可用于确定个体易感性发展为情感障碍和其治疗效果。
