吸烟与NF1突变相关，会加剧胶质瘤的生存结果。

Tobacco smoking associates with NF1 mutations exacerbating survival outcomes in gliomas.

作者信息

Li Xi, Yan Han, Wu Jun, Zhang Longbo

机构信息

Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, 410008, Changsha, China.

National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Central South University, Changsha, 410008, China.

出版信息

Biomark Res. 2022 Nov 9;10(1):78. doi: 10.1186/s40364-022-00430-z.

DOI:10.1186/s40364-022-00430-z

PMID:36352461

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9648001/

Abstract

Tobacco smoking is associated with increased risks of nearly 20 types of cancer. Although the association between smoking and gliomas, the most prevalent type of adult brain tumor, is still unconclusive, here, we found that the frequency of NF1 mutations was significantly increased in the glioma patients with smoking history compared to non-smoking patients (24% vs. 10%, P = 0.021). NF1 acts as a tumor suppressor gene is highly mutated in gliomas. The TCGA data analysis indicated that glioma patients carrying NF1 somatic mutations have worse overall survival (median survival time: smoking 19.9 months vs. non-smoking 36.8 month; P = 0.0018). In addition, we revealed that the NF1 and IDH1 mutations were mutually exclusive suggesting NF1 mutation has independent molecular mechanism involved in glioma biology.

摘要

吸烟与近20种癌症风险增加相关。尽管吸烟与神经胶质瘤（最常见的成人脑肿瘤类型）之间的关联仍无定论，但在此我们发现，有吸烟史的神经胶质瘤患者中NF1突变频率相较于不吸烟患者显著增加（24%对10%，P = 0.021）。NF1作为一种肿瘤抑制基因，在神经胶质瘤中高度突变。TCGA数据分析表明，携带NF1体细胞突变的神经胶质瘤患者总生存期更差（中位生存时间：吸烟患者19.9个月对不吸烟患者36.8个月；P = 0.0018）。此外，我们发现NF1和IDH1突变相互排斥，提示NF1突变在神经胶质瘤生物学中涉及独立的分子机制。