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Increase in treatment of retinopathy of prematurity in the Netherlands from 2010 to 2017.荷兰 2010 年至 2017 年早产儿视网膜病变治疗的增加。
Acta Ophthalmol. 2021 Feb;99(1):97-103. doi: 10.1111/aos.14501. Epub 2020 Jul 23.
4
Strategies to Prevent Severe Retinopathy of Prematurity: A 2020 Update and Meta-analysis.预防早产儿重度视网膜病变的策略：2020 年更新和荟萃分析。
Neoreviews. 2020 Apr;21(4):e249-e263. doi: 10.1542/neo.21-4-e249.
5
Methods to adjust for multiple comparisons in the analysis and sample size calculation of randomised controlled trials with multiple primary outcomes.多主要结局随机对照试验分析和样本量计算中多重比较的调整方法。
BMC Med Res Methodol. 2019 Jun 21;19(1):129. doi: 10.1186/s12874-019-0754-4.
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Use of a Supplemental Oxygen Protocol to Suppress Progression of Retinopathy of Prematurity.使用补充氧气方案抑制早产儿视网膜病变的进展。
Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):887-891. doi: 10.1167/iovs.16-20822.
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Retinopathy of prematurity.早产儿视网膜病变。
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Subgroup analyses in randomized trials: risks of subgroup-specific analyses; power and sample size for the interaction test.随机试验中的亚组分析：亚组特异性分析的风险；交互作用检验的效能和样本量
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关于晚期氧疗策略对早产儿视网膜病变影响的未来研究的考量。

Considerations for future studies on the effect of late phase oxygen strategies on retinopathy of prematurity.

作者信息

Nusman Charlotte M, Schalij-Delfos Nicoline E, Groenwold Rolf H H, Onland Wes

机构信息

Department of Neonatology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Department of Ophthalmology, Leiden University Medical Center, Leiden, Netherlands.

出版信息

Front Pediatr. 2022 Oct 24;10:975613. doi: 10.3389/fped.2022.975613. eCollection 2022.

DOI:10.3389/fped.2022.975613
PMID:36353260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9637967/
Abstract

Strategies to ensure high intraocular oxygen delivery to the developing retina after 32 weeks gestational age, such as higher saturation targets and/or higher hemoglobin levels, are hypothesized to prevent ophthalmological treatment for retinopathy of prematurity (ROP). This short report summarizes the current evidence of these strategies, and discusses possibilities of future studies. A large sample size would be required and therefore the feasibility of a future randomized controlled trial is questioned.

摘要

有假设认为，在孕龄32周后确保向发育中的视网膜提供高眼内氧输送的策略，如更高的饱和度目标和/或更高的血红蛋白水平，可预防早产儿视网膜病变（ROP）的眼科治疗。本简短报告总结了这些策略的现有证据，并讨论了未来研究的可能性。这需要大样本量，因此对未来随机对照试验的可行性提出了质疑。