Posso-Osorio Iván, Rios-Serna Lady J, Rosero Angie M, Cárdenas Diana, Tobón Gabriel J, Cañas Carlos A
Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali 760031, Colombia.
Fundación Valle del Lili, Unidad de Reumatología, Cali, Colombia.
J Transl Autoimmun. 2022 Oct 29;5:100170. doi: 10.1016/j.jtauto.2022.100170. eCollection 2022.
We report a case of 65-year-old male patient with primary hyperparathyroidism (PHPT) who was admitted to the hospital for autoimmune manifestations (including autoimmune hepatitis and autoantibody development) and exhibited subsequent clinical and paraclinical improvement after parathyroidectomy. By flow cytometry, the expression of PTH receptor 1 (PTHR1) on B lymphocytes of peripheral blood was documented to be higher than that in healthy controls. After parathyroidectomy, autoimmune manifestations improved, while PTH1R expression on B-lymphocytes increased. The possible role of the dynamics of B-lymphocyte PTHR1 in the development of this autoimmune phenomenon is discussed.
我们报告一例65岁男性原发性甲状旁腺功能亢进症（PHPT）患者，该患者因自身免疫表现（包括自身免疫性肝炎和自身抗体产生）入院，甲状旁腺切除术后临床及辅助检查结果均有改善。通过流式细胞术检测发现，该患者外周血B淋巴细胞上甲状旁腺激素受体1（PTHR1）的表达高于健康对照者。甲状旁腺切除术后，自身免疫表现有所改善，但B淋巴细胞上PTH1R的表达却增加了。本文讨论了B淋巴细胞PTHR1动态变化在这种自身免疫现象发生发展中的可能作用。
