Li Yifan, Zhou Xianghong, Qiu Shi, Cai Boyu, Wang Sheng, Chen Lei, Hu Dan, Jiang Zhongyuan, Wang Mingda, Xiong Xingyu, Jin Kun, Wei Qiang, Yang Lu, Ma Li
Department of Urology, Institute of Urology, National Clinical Research Center for Geriatrics and Center of Biomedical Big Data, West China Hospital of Sichuan University, Chengdu, China.
West China School of Clinical Medicine, West China Hospital, Sichuan University, Chengdu, China.
Front Aging Neurosci. 2022 Oct 24;14:938407. doi: 10.3389/fnagi.2022.938407. eCollection 2022.
As the population aged, voiding dysfunction has been steadily rising among males during the past decade. Increasing evidence showed that sleep disorders are associated with an increasing risk of various diseases, but the association between sleep disorders and lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) among Chinese males have not been well characterized.
We conducted a cross-sectional analysis of data from West China Natural Population Cohort Study (WCNPCS) 2019-2021. Sleep quality was assessed by Pittsburgh sleep quality index (PSQI) in Chinese version. LUTS/BPH as a dependent variable of a binary variable, assessed by a self-reported questionnaire. Multivariate logistic regression analysis were performed to evaluate the correlation between sleep disorders and the risk of LUTS/BPH after adjusting for confounding factors.
11,824 eligible Chinese men participated in this cross-sectional survey. In multivariate logistic regression analysis, after adjusting for confounding variables, global PSQI score (OR: 1.257, 1.119-1.411, < 0.001) and its six compounds (Subjective sleep quality: OR: 1.376, 1.004-1.886, = 0.048; Sleep latency: OR: 0.656, 0.557-0.773, < 0.001; Sleep duration: OR: 1.441, 1.189-1.745, < 0.001; Habitual sleep efficiency: OR: 1.369, 1.193-1.570, < 0.001; Daytime dysfunction: OR: 1.702, 1.278-2.267, < 0.001) except the use of sleep drug subgroup were significantly positively correlated with LUTS/BPH prevalence. Significant interaction effects were observed in age subgroups (age-young group: age < 51; age-middle group: 51 ≤ age ≤ 61; age-older group: age > 61) ( < 0.05). Among older participants, sleep disorders were more significantly associated with the risk of LUTS/BPH.
There was a significant association between poor sleep quality and increased prevalence of LUTS/BPH, especially among the elderly male population, suggesting an important role of healthy sleep in reducing prostate disease burden.
随着人口老龄化，在过去十年中男性排尿功能障碍一直在稳步上升。越来越多的证据表明，睡眠障碍与各种疾病风险增加有关，但中国男性睡眠障碍与下尿路症状（LUTS）/良性前列腺增生（BPH）之间的关联尚未得到充分描述。
我们对2019 - 2021年中国西部自然人群队列研究（WCNPCS）的数据进行了横断面分析。睡眠质量通过中文版匹兹堡睡眠质量指数（PSQI）进行评估。LUTS/BPH作为二元变量的因变量，通过自我报告问卷进行评估。在调整混杂因素后，进行多因素逻辑回归分析以评估睡眠障碍与LUTS/BPH风险之间的相关性。
11,824名符合条件的中国男性参与了此次横断面调查。在多因素逻辑回归分析中，调整混杂变量后，除使用助眠药物亚组外，PSQI总分（比值比：1.257，1.119 - 1.411，P < 0.001）及其六个成分（主观睡眠质量：比值比：1.376，1.004 - 1.886，P = 0.048；入睡潜伏期：比值比：0.656，0.557 - 0.773，P < 0.001；睡眠时间：比值比：1.441，1.189 - 1.745，P < 0.001；习惯性睡眠效率：比值比：1.369，1.193 - 1.570，P < 0.001；日间功能障碍：比值比：1.702，1.278 - 2.267，P < 0.001）与LUTS/BPH患病率显著正相关。在年龄亚组（青年组：年龄 < 51岁；中年组：51 ≤ 年龄 ≤ 61岁；老年组：年龄 > 61岁）中观察到显著的交互作用（P < 0.05）。在老年参与者中，睡眠障碍与LUTS/BPH风险的关联更为显著。
睡眠质量差与LUTS/BPH患病率增加之间存在显著关联，尤其是在老年男性人群中，这表明健康睡眠在减轻前列腺疾病负担方面具有重要作用。
Zotero 插件
