Zhang Fei, Zhang Andong, Tao Junyue, Zhang Meng, Liang Chaozhao
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Institute of Urology, Anhui Medical University, Hefei, China.
Front Nutr. 2025 Jan 13;11:1511607. doi: 10.3389/fnut.2024.1511607. eCollection 2024.
Coffee is a physiologically active food component prevalent throughout the world, but the association between caffeine intake and benign prostatic hyperplasia (BPH) has been limited in extensive epidemiological studies.
We conducted a cross-sectional study to evaluate the association between caffeine intake and BPH in adults in the United States using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. Caffeine intake (mg/day) was evaluated based on a 24-h dietary recall. Multivariate logistic regression was used to analyze the independent relationship between caffeine intake and BPH, and the results are presented as odds ratio (OR) and 95% confidence interval (CI), subgroup analysis was also performed.
A total of 2,374 participants were analyzed. After fully adjusting for potential confounders, logistic regression analysis revealed that higher caffeine intake was associated with a greater risk of BPH (ORT3vs1 = 1.52, 95% CI: 1.01-2.27; = 0.04). In addition, this relationship was consistently observed across different subgroups, including individuals with lower education levels, a poverty income ratio (PIR) of 1.5 to 3.5, former smokers, married/living with partner individuals, those with uric acid levels of 5.5 to 6.5 mg/dL, those with hypertension, and those without cardiovascular disease (CVD).
This study is the first to find a positive correlation between caffeine intake and BPH, but further research is needed to determine the exact causal relationship between these factors.
咖啡是一种在全球普遍存在的具有生理活性的食物成分，但在广泛的流行病学研究中，咖啡因摄入量与良性前列腺增生（BPH）之间的关联一直有限。
我们进行了一项横断面研究，利用2005 - 2008年美国国家健康与营养检查调查（NHANES）的数据，评估美国成年人咖啡因摄入量与BPH之间的关联。基于24小时饮食回忆评估咖啡因摄入量（毫克/天）。采用多因素逻辑回归分析咖啡因摄入量与BPH之间的独立关系，结果以比值比（OR）和95%置信区间（CI）表示，同时也进行了亚组分析。
共分析了2374名参与者。在对潜在混杂因素进行充分调整后，逻辑回归分析显示，较高的咖啡因摄入量与BPH风险增加相关（ORT3vs1 = 1.52，95% CI：1.01 - 2.27； = 0.04）。此外，在不同亚组中均一致观察到这种关系，包括教育程度较低、贫困收入比（PIR）为1.5至3.5、既往吸烟者、已婚/与伴侣同住者、尿酸水平为5.5至6.5毫克/分升者、患有高血压者以及无心血管疾病（CVD）者。
本研究首次发现咖啡因摄入量与BPH之间存在正相关，但需要进一步研究以确定这些因素之间的确切因果关系。
