Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA.
Translational Molecular Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology and Lab Medicine, Brown University, Providence, RI 02912, USA; Legoretta Cancer Center, Brown University, Providence, RI 021912, USA.
Semin Cancer Biol. 2022 Dec;87:17-31. doi: 10.1016/j.semcancer.2022.10.006. Epub 2022 Oct 27.
Metastatic cancer is almost always terminal, and more than 90% of cancer deaths result from metastatic disease. Combating cancer metastasis and post-therapeutic recurrence successfully requires understanding each step of metastatic progression. This review describes the current state of knowledge of the etiology and mechanism of cancer progression from primary tumor growth to the formation of new tumors in other parts of the body. Open questions, avenues for future research, and therapeutic approaches with the potential to prevent or inhibit metastasis through personalization to each patient's mutation and/or immune profile are also highlighted.
转移性癌症几乎总是致命的，超过 90%的癌症死亡是由转移性疾病引起的。要成功地对抗癌症转移和治疗后复发，需要了解转移进展的每一个步骤。这篇综述描述了目前对癌症从原发性肿瘤生长到在身体其他部位形成新肿瘤的进展的病因和机制的认识。还强调了一些开放性问题、未来研究的途径，以及通过针对每个患者的突变和/或免疫特征进行个性化治疗来预防或抑制转移的潜在治疗方法。
