Auriau Johanne, Usson Yves, Jouk Pierre-Simon
Equipe Biologie Computationnelle et Mathématique, University Grenoble Alpes, CNRS, UMR 5525, VetAgroSup, Grenoble INP, CHU Grenoble Alpes, TIMC, 38000 Grenoble, France.
Service de Cardiologie, CHU Grenoble Alpes, CS 10217, CEDEX 9, 38043 Grenoble, France.
J Cardiovasc Dev Dis. 2022 Oct 29;9(11):371. doi: 10.3390/jcdd9110371.
This is our second article devoted to the cardiac myoarchitecture considered as a nematic chiral liquid crystal (NCLC). While the first article focused on the myoarchitecture of the left ventricle (LV), this new article extends to the whole ventricular mass and introduces the concept of disclinations and topological singularities, which characterize the differences and relationships between the left and right ventricles (RV). At the level of the ventricular apices, we constantly observed a vortex shape at the LV apex, corresponding, in the terminology of liquid crystals, to a "+1 disclination"; we never observed this at the RV apex. At the level of the interventricular septum (IVS), we identified "-1/2 disclinations" at the anterior and posterior parts. During the perinatal period, there was a significant difference in their distribution, with more "-1/2 disclinations" in the posterior part of the IVS. After birth, concomitant to major physiological changes, the number of "-1/2 disclinations" significantly decreased, both in the anterior and posterior parts of the IVS. Finally, the description of the disclinations must be considered in any attempt to segment the whole ventricular mass, in biomechanical studies, and, more generally, for the characterization of myocardial remodeling.
这是我们致力于将心肌结构视为向列型手性液晶（NCLC）的第二篇文章。第一篇文章聚焦于左心室（LV）的心肌结构，而这篇新文章则扩展至整个心室质量，并引入了位错和拓扑奇点的概念，这些概念表征了左心室和右心室（RV）之间的差异与关系。在心室心尖层面，我们在左心室心尖处持续观察到一种涡旋形状，用液晶术语来说，这对应于一个“+1 位错”；而在右心室心尖处从未观察到这种情况。在室间隔（IVS）层面，我们在前部和后部识别出了“-1/2 位错”。在围产期，它们的分布存在显著差异，室间隔后部的“-1/2 位错”更多。出生后，伴随着主要的生理变化，室间隔前部和后部的“-1/2 位错”数量均显著减少。最后，在任何试图对整个心室质量进行分割的尝试中、在生物力学研究中，以及更广泛地说，在心肌重塑的表征中，都必须考虑对位错的描述。
