Ramírez-Manent José Ignacio, Martínez-Almoyna Emilio, López Carlos, Busquets-Cortés Carla, González San Miguel Hilda, López-González Ángel Arturo
ADEMA-SALUD Group of IUNICS, University of Balearic Islands, 07009 Palma, Spain.
Balearic Island Health Service, 07003 Palma, Spain.
Metabolites. 2022 Nov 10;12(11):1093. doi: 10.3390/metabo12111093.
Insulin resistance (IR) has been identified as a key factor in the appearance of non-alcoholic fatty liver disease (NAFLD) as it is related through a complex molecular biochemical and immunological mechanism. Our aim was to evaluate the relationship between different scales that estimate the risk of IR and scales that determine the risk of NAFLD. This descriptive and cross-sectional study was performed in 219,477 Spanish workers from different sectors and Spanish regions. The prevalence of high values of all the IR scales increases as the values of the NAFLD and liver fibrosis scales increase. In the multivariate analysis, the risk of presenting high values in the IR scales increases greatly as the values of the NAFLD and hepatic fibrosis scales increase, with particularly high OR values when using the Metabolic Score for Insulin Resistance (METS-IR) scale (LAP high OR 42.20 (95% CI (39.10-45.56) and FLI high OR 32.35 (95% CI 31.10-33.61)). We can conclude that there is a direct relationship between the values of the IR scales and the NAFLD and liver fibrosis scales in our population.
胰岛素抵抗（IR）已被确定为非酒精性脂肪性肝病（NAFLD）出现的关键因素，因为它通过复杂的分子生化和免疫机制与之相关。我们的目的是评估评估IR风险的不同量表与确定NAFLD风险的量表之间的关系。这项描述性横断面研究在来自西班牙不同部门和地区的219,477名工人中进行。随着NAFLD和肝纤维化量表值的增加，所有IR量表高值的患病率也随之增加。在多变量分析中，随着NAFLD和肝纤维化量表值的增加，IR量表出现高值的风险大幅增加，使用胰岛素抵抗代谢评分（METS-IR）量表时OR值尤其高（LAP高OR 42.20（95%CI（39.10 - 45.56））和FLI高OR 32.35（95%CI 31.10 - 33.61））。我们可以得出结论，在我们的人群中，IR量表值与NAFLD和肝纤维化量表值之间存在直接关系。
