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Genetically Predicted Lipid Traits, Diabetes Liability, and Carotid Intima-Media Thickness in African Ancestry Individuals: A Mendelian Randomization Study.

作者信息

Soremekun Opeyemi, Slob Eric A W, Burgess Stephen, Romuald Boua Palwende, Fatumo Segun, Gill Dipender

机构信息

The African Computational Genomics (TACG) Research Group, Entebbe, Uganda (O.S., S.F.).

Medical Rsrch Council Biostatistics Unit, University of Cambridge, UK (E.A.W.S., S.B.).

出版信息

Circ Genom Precis Med. 2022 Dec;15(6):e003910. doi: 10.1161/CIRCGEN.122.003910. Epub 2022 Nov 10.

DOI:10.1161/CIRCGEN.122.003910
PMID:36355609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7613981/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/811f/7613981/764d51bf4304/EMS156528-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/811f/7613981/764d51bf4304/EMS156528-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/811f/7613981/764d51bf4304/EMS156528-f001.jpg

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Front Cell Infect Microbiol. 2023 May 2;13:1171517. doi: 10.3389/fcimb.2023.1171517. eCollection 2023.

本文引用的文献

1
Guidelines for performing Mendelian randomization investigations: update for summer 2023.孟德尔随机化研究实施指南：2023年夏季更新版
Wellcome Open Res. 2023 Aug 4;4:186. doi: 10.12688/wellcomeopenres.15555.3. eCollection 2019.
2
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.在一项多血统荟萃分析中，对 140 万参与者进行研究，发现了 318 个 2 型糖尿病和相关血管结局的新风险位点。
Nat Genet. 2020 Jul;52(7):680-691. doi: 10.1038/s41588-020-0637-y. Epub 2020 Jun 15.
3
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
GWAS 和共定位分析提示颈动脉内膜中层厚度和颈动脉斑块部位与心血管结局相关。
Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5.
4
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.《百万退伍军人计划中约 30 万多民族参与者的血脂遗传学》。
Nat Genet. 2018 Nov;50(11):1514-1523. doi: 10.1038/s41588-018-0222-9. Epub 2018 Oct 1.