Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, United States.
Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, United States.
Prog Mol Biol Transl Sci. 2022;193(1):167-176. doi: 10.1016/bs.pmbts.2022.06.007. Epub 2022 Jul 20.
GPR158 is an orphan G protein-coupled receptor (GPCR) that is broadly expressed in the brain and displays unique structural characteristics and signaling mechanisms. GPR158 is a binding partner for the regulator of G protein signaling 7 (RGS7) and augments its expression, subcellular localization, and catalytic activity. Recent cryo-electron microscopy (cryo-EM) studies have revealed the structure of GPR158 alone and in complex with RGS7. The GPR158-RGS7 complex is shown to be regulated by chronic stress exposure and is a modulator of stress-induced depression. This review highlights the signaling mechanism and function of GPR158-RGS7 and provides a context for the unique formation of GPCR-RGS complexes.
GPR158 是一种孤儿 G 蛋白偶联受体 (GPCR)，广泛表达于大脑中，并具有独特的结构特征和信号转导机制。GPR158 是 G 蛋白信号调节因子 7（RGS7）的结合伴侣，并增强其表达、亚细胞定位和催化活性。最近的冷冻电镜（cryo-EM）研究揭示了 GPR158 单独和与 RGS7 复合物的结构。研究表明，GPR158-RGS7 复合物受慢性应激暴露的调节，是应激诱导抑郁的调节剂。本综述强调了 GPR158-RGS7 的信号转导机制和功能，并为 GPCR-RGS 复合物的独特形成提供了背景。
