Beijing Children's Hospital, Capital Medical University, National Center for Children's Healthy, Beijing, China.
National Center for Pediatric Center Surveillance, Beijing Children's Hospital, Capital Medical University, National Center for Children's Healthy, Beijing, China.
J Cancer Res Clin Oncol. 2023 Mar;149(3):1313-1318. doi: 10.1007/s00432-022-04466-4. Epub 2022 Nov 10.
To analyze the safety and efficacy of Pars Plana Vitrectomy (PPV) as a treatment for retinoblastoma patients and to evaluate the feasibility.
We collected 342 eyes who had PPV after systemic chemotherapy in our retrospective study, then analyze the 5-year overall survival and 5-year event-free survival rate, recurrence rate, and metastasis rate. The above data were used to evaluate the feasibility of PPV in the treatment of retinoblastoma.
The mean value of follow-up time was 62.9 months from PPV. Of all 342 eyes, 18% eyes underwent enucleation of the eyeball. Excluding Non-PPV related deaths eyes, the 5-year overall survival rates and event-free survival were 95% and 80%; the tumor recurrence rate and metastasis rate were approximately 26% and 1.2%, respectively; the mortality was 3.9%. And the incidence of high-risk pathological factors of enucleated eyes after PPV was 32%.
Our results suggest that Pars Plana Vitrectomy as a new approach to preserve the eyeball of RB children is feasible, especially for those patients who cannot be completely controlled by systemic chemotherapy or the tumors with vitreous seeds. Although the outcomes in our study are very optimistic, we also recommend an experienced eye surgeon to perform the operation and strictly control the indications for PPV surgery. And enough systemic chemotherapy is very important before and after surgery.
Treatment study (Retrospective comparative study), III.
分析玻璃体切割术（PPV）作为治疗视网膜母细胞瘤（RB）患者的安全性和有效性，并评估其可行性。
我们进行了一项回顾性研究，共纳入 342 只接受全身化疗后行 PPV 的患眼，分析其 5 年总生存率、5 年无事件生存率、复发率和转移率。通过上述数据评估 PPV 在 RB 治疗中的可行性。
从行 PPV 至末次随访的平均时间为 62.9 个月。所有 342 只眼中，18%的患眼行眼球摘除术。排除与 PPV 无关的死亡眼后，5 年总生存率和无事件生存率分别为 95%和 80%；肿瘤复发率和转移率约为 26%和 1.2%，死亡率为 3.9%；行 PPV 后眼球摘除眼的高危病理因素发生率为 32%。
我们的研究结果表明，PPV 作为一种保留 RB 患儿眼球的新方法是可行的，特别是对于那些不能通过全身化疗完全控制或肿瘤存在玻璃体内播散的患者。虽然我们的研究结果非常乐观，但我们仍建议由经验丰富的眼科医生来进行手术，并严格控制 PPV 手术的适应证。并且手术前后足够的全身化疗非常重要。
治疗研究（回顾性对比研究），III 级。
