Ilyés Tamás, Silaghi Ciprian N, Crăciun Alexandra M
Department of Molecular Sciences, University of Medicine and Pharmacy "Iuliu Hațieganu", 400012 Cluj-Napoca, Romania.
Biology (Basel). 2022 Oct 24;11(11):1556. doi: 10.3390/biology11111556.
Obesity-related illnesses are one of the leading causes of death worldwide. Metabolic syndrome has been associated with numerous health issues. Short-chain fatty acids (SCFAs) have been shown to have multiple effects throughout the body, both directly as well as through specific G protein-coupled receptors. The main SCFAs produced by the gut microbiota are acetate, propionate, and butyrate, which are absorbed in varying degrees from the large intestine, with some acting mainly locally and others systemically. Diet has the potential to influence the gut microbial composition, as well as the type and amount of SCFAs produced. High fiber-containing foods and supplements increase the production of SCFAs and SCFA-producing bacteria in the gut and have been shown to have bodyweight-lowering effects. Dietary supplements, which increase SCFA production, could open the way for novel approaches to weight loss interventions. The aim of this review is to analyze the variations of fecal and blood SCFAs in obesity and metabolic syndrome through a systematic search and analysis of existing literature.
肥胖相关疾病是全球主要死因之一。代谢综合征与众多健康问题相关。短链脂肪酸（SCFAs）已被证明在全身具有多种作用，既可直接作用，也可通过特定的G蛋白偶联受体发挥作用。肠道微生物群产生的主要短链脂肪酸是乙酸盐、丙酸盐和丁酸盐，它们从大肠中不同程度地被吸收，有些主要在局部起作用，有些则在全身起作用。饮食有可能影响肠道微生物组成，以及所产生的短链脂肪酸的类型和数量。高纤维食物和补充剂会增加肠道中短链脂肪酸和产生短链脂肪酸的细菌的生成，并且已被证明具有降低体重的作用。增加短链脂肪酸生成的膳食补充剂可能为减肥干预的新方法开辟道路。本综述的目的是通过对现有文献的系统检索和分析，分析肥胖和代谢综合征中粪便和血液短链脂肪酸的变化。
