Kuo Tzu-Hsin, Sneddon Lynne U, Spencer Joseph W, Chiao Chuan-Chin
Institute of Systems Neuroscience, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan.
Department of Biological & Environmental Sciences, University of Gothenburg, P.O. Box 463, SE-405 30 Gothenburg, Sweden.
Biology (Basel). 2022 Oct 24;11(11):1560. doi: 10.3390/biology11111560.
Nociception is the neural process of encoding noxious stimuli and is typically accompanied by a reflex withdrawal response away from the potentially injurious stimulus. Studies on nociception in cephalopods have so far focused on octopus and squid, with no investigations to our knowledge on cuttlefish. Yet, these are an important species both in scientific and commercial use. Therefore, the present study demonstrated that a standard pain stimulus, acetic acid, induced grooming behaviour directed towards the injection site in cuttlefish and that the injection of lidocaine reduces grooming behaviours in acetic-acid-injected cuttlefish. Wound-directed behaviour demonstrates that the animal is aware of the damage; thus, when subjecting these animals to any painful treatments in the laboratory, researchers should consider alleviating pain by the administration of pain-relieving drugs.
伤害感受是对有害刺激进行编码的神经过程，通常伴随着远离潜在有害刺激的反射性退缩反应。迄今为止，关于头足类动物伤害感受的研究主要集中在章鱼和鱿鱼上，据我们所知，尚未有对乌贼的研究。然而，乌贼在科学研究和商业应用中都是重要的物种。因此，本研究表明，标准的疼痛刺激物醋酸会诱发乌贼针对注射部位的梳理行为，并且注射利多卡因会减少注射醋酸的乌贼的梳理行为。针对伤口的行为表明动物意识到了损伤；因此，当在实验室中对这些动物进行任何疼痛处理时，研究人员应考虑通过给予止痛药物来减轻疼痛。
