Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, China.
Biomolecules. 2022 Nov 3;12(11):1624. doi: 10.3390/biom12111624.
Common uterine diseases include endometriosis, uterine fibroids, endometrial polyps, endometrial hyperplasia, endometrial cancer, and endometrial dysfunction causing infertility. Patients with uterine diseases often suffer from abdominal pain, menorrhagia, infertility and other symptoms, which seriously impair their health and disturb their lives. Androgens play important roles in the normal physiological functions of the uterus and pathological progress of uterine diseases. Androgens in women are synthesized in the ovaries and adrenal glands. The action of androgens in the uterus is mainly mediated by its ligand androgen receptor (AR) that regulates transcription of the target genes. However, much less is known about the signaling pathways through which androgen functions in uterine diseases, and contradictory findings have been reported. This review summarizes and discusses the progress of research on androgens and the involvement of AR in uterine diseases. Future studies should focus on developing new therapeutic strategies that precisely target specific AR and their related signaling pathways in uterine diseases.
常见的子宫疾病包括子宫内膜异位症、子宫肌瘤、子宫内膜息肉、子宫内膜增生、子宫内膜癌和导致不孕的子宫内膜功能障碍。患有子宫疾病的患者常出现腹痛、月经过多、不孕等症状，严重损害其健康，扰乱其生活。雄激素在子宫的正常生理功能和子宫疾病的病理进展中发挥重要作用。女性的雄激素在卵巢和肾上腺中合成。雄激素在子宫中的作用主要通过其配体雄激素受体（AR）介导，调节靶基因的转录。然而，关于雄激素在子宫疾病中的作用信号通路知之甚少，并且已有报道存在相互矛盾的结果。本文综述并讨论了雄激素和 AR 参与子宫疾病的研究进展。未来的研究应侧重于开发新的治疗策略，以精确靶向子宫疾病中特定的 AR 及其相关信号通路。
