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肥胖在子宫内膜癌病因学及致癌过程中的作用

The Role of Obesity in the Etiology and Carcinogenesis of Endometrial Cancer.

作者信息

Marin Alina-Gabriela, Filipescu Alexandru, Petca Aida

机构信息

Obstetrics and Gynaecology, Elias Emergency University Hospital, Bucharest, ROU.

Obstetrics and Gynaecology, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.

出版信息

Cureus. 2024 Apr 28;16(4):e59219. doi: 10.7759/cureus.59219. eCollection 2024 Apr.

DOI:10.7759/cureus.59219
PMID:38807790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11132319/
Abstract

Endometrial cancer, the most common gynecological malignancy, presents a complex public health challenge. While its incidence rises alongside the obesity epidemic, a well-established risk factor for endometrial cancer development, the impact of obesity on survival after diagnosis remains unclear. This review aims to explore the complex relationship between obesity and endometrial cancer's development and survival rates, examining evidence from both epidemiological and clinical studies. It also aims to explore the proposed biological mechanisms by which excess adipose tissue promotes carcinogenesis and contributes to endometrial cancer progression and its negative effects on treatment outcomes. Furthermore, we analyzed the impact of body mass index, inflammation, hormonal imbalances, and their potential effects on endometrial cancer survival rates.

摘要

子宫内膜癌是最常见的妇科恶性肿瘤，带来了复杂的公共卫生挑战。虽然其发病率随着肥胖流行而上升，肥胖是子宫内膜癌发生的一个已明确的风险因素，但肥胖对诊断后生存的影响仍不明确。本综述旨在探讨肥胖与子宫内膜癌发生及生存率之间的复杂关系，审视来自流行病学和临床研究的证据。它还旨在探究多余脂肪组织促进致癌作用并导致子宫内膜癌进展及其对治疗结果产生负面影响的假定生物学机制。此外，我们分析了体重指数、炎症、激素失衡的影响及其对子宫内膜癌生存率的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/127919b8317a/cureus-0016-00000059219-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/0286acb33d52/cureus-0016-00000059219-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/ddcc04a9fc0e/cureus-0016-00000059219-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/026f17fff70b/cureus-0016-00000059219-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/127919b8317a/cureus-0016-00000059219-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/0286acb33d52/cureus-0016-00000059219-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/ddcc04a9fc0e/cureus-0016-00000059219-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/026f17fff70b/cureus-0016-00000059219-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/999d/11132319/127919b8317a/cureus-0016-00000059219-i04.jpg

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