Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang 110134, China.
Department of Orthopaedics, Shengjing Hospital of China Medical University, Shenyang 110134, China.
Biomolecules. 2022 Nov 8;12(11):1653. doi: 10.3390/biom12111653.
β2 integrins are transmembrane receptors that exist widely in human immune cells and participate in pathological processes such as chronic inflammation, thrombosis, and malignant tumor formation. They mainly mediate intercellular adhesion, coordinate the ingestion of extracellular matrix components, and regulate cytoskeleton formation, thereby regulating cell signaling. Osteoarthritis (OA) is a chronic joint disease that causes joint pain and increases disease burden; it has a high prevalence among populations worldwide. Previous studies have reported that β2 integrins are overexpressed in OA and may play an essential role in the occurrence of OA. The important roles of β2 integrins in the maturation and differentiation of osteoclasts, the regulation of bone homeostasis, and the polarization and migration of macrophages have also been reported. The present review aims to highlight the role of β2 integrins in OA pathogenesis and outline their potential for serving as therapeutic targets.
β2 整合素是一种广泛存在于人类免疫细胞中的跨膜受体，参与慢性炎症、血栓形成和恶性肿瘤形成等病理过程。它们主要介导细胞间黏附，协调细胞外基质成分的摄取，并调节细胞骨架形成，从而调节细胞信号转导。骨关节炎（OA）是一种慢性关节疾病，会引起关节疼痛并增加疾病负担；它在全球人群中的患病率很高。先前的研究报告称，β2 整合素在 OA 中过度表达，可能在 OA 的发生中起重要作用。β2 整合素在破骨细胞的成熟和分化、骨稳态的调节以及巨噬细胞的极化和迁移中的重要作用也有报道。本综述旨在强调β2 整合素在 OA 发病机制中的作用，并概述其作为治疗靶点的潜力。
