Bulai Catalin, Geavlete Petrisor, Ene Cosmin-Victor, Bulai Isabela, Popescu Razvan-Ionut, Mares Cristian, Ene Corina Daniela, Punga Ana-Maria, Geavlete Bogdan
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
"Saint John" Emergency Clinical Hospital, 042122 Bucharest, Romania.
Diagnostics (Basel). 2022 Nov 4;12(11):2696. doi: 10.3390/diagnostics12112696.
Early detection of bladder cancer has a positive impact on prognosis. A variety of biomarkers have been developed to detect bladder tumors in urine early and reduce the need for cystoscopy. To detect bladder cancer, several methods are available, but their accuracy varies according to the sensitivity and specificity of each method. This review aims to highlight the established detection methods for bladder cancer based on the available literature. In addition, we aim to identify the combination of different effective detection methods that provides the highest degree of accuracy. In our study, a keyword retrieval method was used to search for appropriate English-language references. This bibliography has been indexed in PubMed and Scopus or has been found through systematic searches from 2015 to 2022. Based on an analysis of international guidelines, it has been revealed that there are numerous discrepancies and unresolved issues. The discovery of an ideal detection method for urothelial cell carcinoma biomarkers has been the subject of numerous efforts. In recent years, a wide range of off-label, experimental, novel, and combined approaches have been published on this topic. This review can contribute to the identification of accurate methods of detecting bladder cancer and highlight areas for future research that can be improved.
膀胱癌的早期检测对预后有积极影响。已经开发出多种生物标志物来早期检测尿液中的膀胱肿瘤，并减少膀胱镜检查的需求。为了检测膀胱癌，有几种方法可供选择，但它们的准确性根据每种方法的敏感性和特异性而有所不同。本综述旨在根据现有文献突出已确立的膀胱癌检测方法。此外，我们旨在确定能提供最高准确度的不同有效检测方法的组合。在我们的研究中，使用关键词检索方法来搜索合适的英文参考文献。该参考文献已在PubMed和Scopus中索引，或通过2015年至2022年的系统搜索找到。基于对国际指南的分析，发现存在许多差异和未解决的问题。寻找尿路上皮细胞癌生物标志物的理想检测方法一直是众多努力的主题。近年来，关于这一主题已经发表了广泛的非标签、实验性、新颖性和联合性方法。本综述有助于确定检测膀胱癌的准确方法，并突出未来可改进的研究领域。
