Thoracic Surgery Laboratory, Xuzhou Medical University, 84 West Huaihai Road, Xuzhou 221006, China.
Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou 221006, China.
Cells. 2022 Oct 31;11(21):3438. doi: 10.3390/cells11213438.
The malignancy with the greatest global mortality rate is lung cancer. Lung adenocarcinoma (LUAD) is the most common subtype. The evidence demonstrated that voltage-gated potassium channel subunit beta-2 (KCNAB2) significantly participated in the initiation of colorectal cancer and its progression. However, the biological function of KCNAB2 in LUAD and its effect on the tumor immune microenvironment are still unknown. In this study, we found that the expression of KCNAB2 in tissues of patients with LUAD was markedly downregulated, and its downregulation was linked to accelerated cancer growth and poor clinical outcomes. In addition, low KCNAB2 expression was correlated with a deficiency in immune infiltration. The mechanism behind this issue might be that KCNAB2 influenced the immunological process such that the directed migration of immune cells was affected. Furthermore, overexpression of KCNAB2 in cell lines promoted the expression of CCL2, CCL3, CCL4, CCL18, CXCL9, CXCL10, and CXCL12, which are necessary for the recruitment of immune cells. In conclusion, KCNAB2 may play a key function in immune infiltration and can be exploited as a predictive biomarker for evaluating prognosis and a possible immunotherapeutic target.
全球死亡率最高的恶性肿瘤是肺癌。肺腺癌（LUAD）是最常见的亚型。有证据表明，电压门控钾通道亚基β-2（KCNAB2）显著参与了结直肠癌的发生和进展。然而，KCNAB2 在 LUAD 中的生物学功能及其对肿瘤免疫微环境的影响尚不清楚。在本研究中，我们发现 LUAD 患者组织中 KCNAB2 的表达明显下调，其下调与癌症生长加速和临床预后不良有关。此外，低 KCNAB2 表达与免疫浸润不足有关。造成这个问题的原因可能是 KCNAB2 影响了免疫过程，导致免疫细胞的定向迁移受到影响。此外，细胞系中 KCNAB2 的过表达促进了 CCL2、CCL3、CCL4、CCL18、CXCL9、CXCL10 和 CXCL12 的表达，这些都是招募免疫细胞所必需的。总之，KCNAB2 可能在免疫浸润中发挥关键作用，并可作为评估预后和可能的免疫治疗靶点的预测生物标志物。
