犹他州家族中激肽释放酶排泄的环境家族性证据。
Evidence for environmental familiality of kallikrein excretion in Utah kindreds.
作者信息
Dadone M M, Smith J B, Anderton D L, Ash K O, Williams R R
出版信息
West J Med. 1986 May;144(5):559-63.
In investigating the role of urinary kallikrein in the pathophysiology of hypertension, we measured 12-hour kallikrein excretion in 1,100 persons in 68 Utah kindreds. The kallikrein excretion was statistically adjusted to account for variations in body size and urine output. Adjusted kallikrein excretion was greater in youths than in adults and correlated with potassium excretion and sodium excretion in persons with normal blood pressure. It was decreased in normotensive subjects with strong family histories of stroke and hypertension, but was not significantly different in adults with hypertension. Adjusted kallikrein excretion was correlated between pairs of siblings, parent-offspring pairs and spouses. Our results indicate that kallikrein excretion is a familial variable, with the familiality due more to shared environmental than genetic factors.
在研究尿激肽释放酶在高血压病理生理学中的作用时，我们测量了犹他州68个家族中1100人的12小时激肽释放酶排泄量。对激肽释放酶排泄量进行了统计学调整，以考虑体型和尿量的变化。调整后的激肽释放酶排泄量在年轻人中高于成年人，并且与血压正常者的钾排泄和钠排泄相关。在有中风和高血压家族史的血压正常受试者中，激肽释放酶排泄量降低，但在高血压成年人中无显著差异。调整后的激肽释放酶排泄量在同胞对、亲子对和配偶之间具有相关性。我们的结果表明，激肽释放酶排泄是一个家族性变量，家族性更多地归因于共同的环境因素而非遗传因素。
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