Kurasawa Yasuhiro, Iida Akihiko, Narimatsu Kaya, Sekiya Hideki, Maruoka Yutaka, Michiwaki Yukihiro
Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8520, Japan.
Department of Dentistry and Oral Surgery, Nagaoka Red Cross Hospital, Niigata 940-2085, Japan.
J Clin Med. 2022 Nov 6;11(21):6576. doi: 10.3390/jcm11216576.
Perioperative oral management (POM) is used to prevent pneumonia in patients with cancer. However, the factors that expose hospitalized patients to increased risk of developing pneumonia remain unclear. For example, no study to date has compared the incidence of pneumonia in hospitalized patients by cancer primary lesion, or POM implementation, or not. We determined which patients were most likely to benefit from POM and examined the effects of POM on pneumonia prevention and mortality. In a total of 9441 patients with cancer who underwent surgery during hospitalization, there were 8208 patients in the No POM group, and 1233 in the POM group. We examined between-group differences in the incidence of pneumonia and associated outcomes during hospitalization. There was no significant between-group difference in the incidence of pneumonitis, however, patients with lung, or head and neck cancers, demonstrated a lower incidence of postoperative pneumonia. Among patients with lung and pancreatic cancers, mortality was significantly lower in the POM group. POM appears effective at reducing the risk of postoperative pneumonia in patients with certain cancers. Further, mortality was significantly lower in patients with lung and pancreatic cancers who received POM; hence, POM may be an effective adjuvant therapy for patients with cancer.
围手术期口腔管理（POM）用于预防癌症患者发生肺炎。然而，使住院患者发生肺炎风险增加的因素仍不明确。例如，迄今为止尚无研究比较过因癌症原发灶、是否实施POM等因素导致的住院患者肺炎发病率。我们确定了哪些患者最有可能从POM中获益，并研究了POM对预防肺炎和降低死亡率的效果。在总共9441例住院期间接受手术的癌症患者中，无POM组有8208例患者，POM组有1233例患者。我们研究了两组患者住院期间肺炎发病率及相关结果的组间差异。肺炎发病率在组间无显著差异，然而，肺癌或头颈癌患者术后肺炎发病率较低。在肺癌和胰腺癌患者中，POM组的死亡率显著较低。POM似乎能有效降低某些癌症患者术后肺炎的风险。此外，接受POM的肺癌和胰腺癌患者死亡率显著较低；因此，POM可能是癌症患者的一种有效辅助治疗方法。
