Department of Intensive Care, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Medicina (Kaunas). 2022 Oct 24;58(11):1515. doi: 10.3390/medicina58111515.
Multisystem Inflammatory Syndrome (MIS) is a rare but increasingly recognized complication of SARS-CoV-2 infection, usually presenting 2 to 6 weeks after the onset of COVID-19 infection symptoms and affecting mainly children. However, there have been reported several cases of a similar multisystem inflammatory syndrome in adults (MIS-A). We describe the case of a previously healthy 28-year-old male who presented with a clinical profile with multiorgan involvement within four weeks after confirmed SARS-CoV-2 infection, suggestive for multisystem inflammatory syndrome (MIS-A). The clinical presentation included persistent high grade of fever, gastrointestinal and mucocutaneous lesions, lymphadenopathy, elevated cardiac and inflammatory biomarkers, cytopenia and shock. This case report illustrates the wide range of presentations, diagnosis, and treatment modalities of multisystem inflammatory syndrome. The pathophysiology and the mechanisms by which SARS-CoV-2 triggers an abnormal immune response leading to MIS remain poorly understood. Better characterization of MIS-A and early recognition of MIS is important because it is associated with high mortality if left untreated.
多系统炎症综合征（MIS）是 SARS-CoV-2 感染的一种罕见但日益被认识到的并发症，通常在 COVID-19 感染症状出现后 2 至 6 周出现，主要影响儿童。然而，已有报道称成年人也存在类似的多系统炎症综合征（MIS-A）。我们描述了一例先前健康的 28 岁男性，在确诊 SARS-CoV-2 感染后 4 周内出现多器官受累的临床特征，提示为多系统炎症综合征（MIS-A）。临床表现包括持续高热、胃肠道和黏膜皮肤损伤、淋巴结病、心脏和炎症生物标志物升高、细胞减少和休克。本病例报告说明了多系统炎症综合征的广泛表现、诊断和治疗方式。SARS-CoV-2 引发异常免疫反应导致 MIS 的病理生理学和机制仍知之甚少。更好地描述 MIS-A 并早期识别 MIS 很重要，因为如果不治疗，它会导致高死亡率。
