Kimchi A, Gotsman M S, Lewis B S
Isr J Med Sci. 1978 Sep;14(9):941-7.
The clinical effects of a new cardioselective beta-adrenergic blocking drug, acebutolol hydrochloride (SECTRAL), were studied in 18 patients with angina pectoris, using graded treadmill testing according to a modified Bruce protocol. Measurements were made in the control state, after two weeks' treatment with placebo and after two more weeks of constant oral dose of the drug. Acebutolol produced a significant increase in the treadmill work performed before the onset of ischemic ECG changes and chest pain. The heart rate and blood pressure responses to exercise were depressed, so that the greater work load was achieved at a lower double product. Graded treadmill testing is a useful method for assessing the efficacy of treatment with a beta-blocking drug.
采用改良的布鲁斯方案进行分级运动平板试验，对18例心绞痛患者研究了一种新型心脏选择性β-肾上腺素能阻滞剂盐酸醋丁洛尔（心得静）的临床疗效。在对照状态、服用安慰剂两周后以及继续口服该药物两周恒定剂量后进行测量。醋丁洛尔使缺血性心电图改变和胸痛发作前的运动平板功显著增加。运动时的心率和血压反应降低，因此在较低的双乘积下能达到更大的工作量。分级运动平板试验是评估β-阻滞剂治疗效果的一种有用方法。
