Admon D, Kamchi A, Lewis B S, Gotsman M S
Isr J Med Sci. 1979 Mar;15(3):207-11.
The clinical effect of the beta-adrenergic blocking drug acebutolol hydrochloride (SECTRAL) was studied in 18 patients with angina pectoris. Ambulatory 24-h ECG monitoring proved to be a useful method for assessing the efficacy of this drug in individual patients in their own daily stresses and environment. Patients were studied in the control state, after two weeks' treatment with placebo, and after two weeks' constant oral dose of the drug. It was found that acebutolol produced a significant decrease in ischemic ST segment depression in patients in whom good beta-blockade was achieved. The drug was less effective in patients in whom the heart rate response to exercise was not suppressed and in those with critical coronary artery obstructions.
对18例心绞痛患者研究了β-肾上腺素能阻滞剂盐酸醋丁洛尔（ Sectral）的临床疗效。动态24小时心电图监测被证明是评估该药物在个体患者日常压力和环境中的疗效的有用方法。在对照状态下、服用安慰剂两周后以及持续口服该药物两周后对患者进行了研究。结果发现，在实现良好β受体阻滞的患者中，醋丁洛尔使缺血性ST段压低显著降低。在心率对运动的反应未被抑制的患者以及冠状动脉严重阻塞的患者中，该药物效果较差。
