School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
Molecules. 2022 Oct 31;27(21):7269. doi: 10.3390/molecules27217269.
Breast cancer (BC) is a serious global challenge, and depression is one of the risk factors and comorbidities of BC. Recently, the research on the comorbidity of BC and depression has focused on the dysfunction of the hypothalamic-pituitary-adrenal axis and the persistent stimulation of the inflammatory response. However, the further mechanisms for comorbidity remain unclear. Epoxide metabolism has been shown to have a regulatory function in the comorbid mechanism with scattered reports. Hence, this article reviews the role of epoxide metabolism in depression and BC. The comprehensive review discloses the imbalance in epoxide metabolism and its downstream effect shared by BC and depression, including overexpression of inflammation, upregulation of toxic diols, and disturbed lipid metabolism. These downstream effects are mainly involved in the construction of the breast malignancy microenvironment through liver regulation. This finding provides new clues on the mechanism of BC and depression comorbidity, suggesting in particular a potential relationship between the liver and BC, and provides potential evidence of comorbidity for subsequent studies on the pathological mechanism.
乳腺癌（BC）是一个严重的全球性挑战，而抑郁是其风险因素和合并症之一。最近，关于 BC 和抑郁合并症的研究集中在下丘脑-垂体-肾上腺轴功能障碍和炎症反应持续刺激上。然而，合并症的进一步机制尚不清楚。环氧化物代谢在合并机制中具有调节作用，这方面的报道较为零散。因此，本文综述了环氧化物代谢在抑郁和 BC 中的作用。综合分析揭示了 BC 和抑郁共有的环氧化物代谢失衡及其下游效应，包括炎症过度表达、毒性二醇上调和脂质代谢紊乱。这些下游效应主要通过肝脏调节参与构建乳腺癌恶性微环境。这一发现为 BC 和抑郁合并症的发病机制提供了新的线索，特别是提示了肝脏与 BC 之间可能存在的关系，并为后续研究病理机制提供了合并症的潜在证据。
