Division of Vascular Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Molecules. 2022 Nov 3;27(21):7524. doi: 10.3390/molecules27217524.
Vascular metabolic dysfunction presents in various diseases, such as atherosclerosis, hypertension, and diabetes mellitus. Due to the high prevalence of these diseases, it is important to explore treatment strategies to protect vascular function. Resveratrol (RSV), a natural polyphenolic phytochemical, is regarded as an agent to regulate metabolic pathways. Many studies have proven that RSV has beneficial effects on improving metabolism in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), which provide new directions to treat vascular metabolic diseases. Herein, we overviewed that RSV could regulate cell metabolism activity by inhibiting glucose uptake, suppressing glycolysis, preventing cells from fatty acid-related damages, reducing lipogenesis, increasing fatty acid oxidation, enhancing lipolysis, elevating uptake and synthesis of glutamine, and increasing NO release. Furthermore, in clinical trials, although the results from different studies remain controversial, we proposed that RSV had better therapeutic effects at high concentrations and for patients with metabolic disorders.
血管代谢功能障碍可出现在多种疾病中，如动脉粥样硬化、高血压和糖尿病等。由于这些疾病的高发病率，探索保护血管功能的治疗策略非常重要。白藜芦醇（RSV）是一种天然多酚类植物化学物质，被认为是调节代谢途径的一种物质。许多研究已经证明 RSV 对改善内皮细胞（ECs）和血管平滑肌细胞（VSMCs）中的代谢有有益的影响，为治疗血管代谢疾病提供了新的方向。在此，我们综述了 RSV 通过抑制葡萄糖摄取、抑制糖酵解、防止细胞发生与脂肪酸相关的损伤、减少脂肪生成、增加脂肪酸氧化、增强脂肪分解、增加谷氨酰胺摄取和合成以及增加一氧化氮（NO）释放来调节细胞代谢活性。此外，在临床试验中，尽管来自不同研究的结果仍存在争议，但我们提出 RSV 在高浓度时和对代谢紊乱的患者具有更好的治疗效果。
