International Tomography Center SB RAS, Institutskaya Str. 3a, 630090 Novosibirsk, Russia.
Novosibirsk State University, Pirogova Str. 1, 630090 Novosibirsk, Russia.
Molecules. 2022 Nov 3;27(21):7545. doi: 10.3390/molecules27217545.
The 2-imidazoline nitroxide derivatives of cymantrene-2-(-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1-imidazole-3-oxide-1-oxyl (NNMn) and 2-(-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1-imidazole-1-oxyl (INMn) were synthesized. It was shown that NNMn and INMn exhibit a sufficiently high kinetic stability both in solids and in solutions under normal conditions. Their structural characteristics, magnetic properties and electrochemical behavior are close to Re(I) analogs. This opens the prospect of using paramagnetic cymantrenes as prototypes in the design of Re(I) half-sandwiched derivatives for theranostics, where therapy is combined with diagnostics by magnetic resonance imaging due to the contrast properties of nitroxide radicals.
合成了金刚烷-2-(-环戊二烯基)三羰基合锰(I)-4,4,5,5-四甲基-4,5-二氢-1-咪唑-3-氧化物-1-氧自由基（NNMn）和 2-(-环戊二烯基)三羰基合锰(I)-4,4,5,5-四甲基-4,5-二氢-1-咪唑-1-氧自由基（INMn）的 2-咪唑啉氮氧化物衍生物。结果表明，NNMn 和 INMn 在正常条件下无论是在固体还是在溶液中都表现出足够高的动力学稳定性。它们的结构特征、磁性能和电化学行为与 Re(I)类似物接近。这为将顺磁金刚烷作为设计 Re(I)半夹心衍生物的原型用于治疗学开辟了前景，在治疗学中，由于氮氧化物自由基的对比性质，通过磁共振成像将治疗与诊断结合在一起。
