Department of Nuclear Medicine and Molecular Imaging, Radiological Sciences Division, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.
Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Molecules. 2022 Nov 7;27(21):7646. doi: 10.3390/molecules27217646.
Yttrium-90 (Y) microspheres are widely used for the treatment of liver-dominant malignant tumors. They are infused via catheter into the hepatic artery branches supplying the tumor under fluoroscopic guidance based on pre-therapy angiography and Technetium-99m macroaggregated albumin (Tc-MAA) planning. However, at present, these microspheres are suspended in radiolucent media such as dextrose 5% (D5) solution. In order to monitor the real-time implantation of the microspheres into the tumor, the Y microspheres could be suspended in omnipaque contrast for allowing visualization of the correct distribution of the microspheres into the tumor. The radiochemical purity of mixing Y-microspheres in various concentrations of omnipaque was investigated. The radiochemical purity and feasibility of mixing Tc-MAA with various concentrations of a standard contrast agent were also investigated. Results showed the radiochemical feasibility of mixing Y-microspheres with omnipaque is radiochemically acceptable for allowing real-time visualization of radioembolization under fluoroscopy.
钇 90（Y）微球被广泛用于治疗肝脏为主的恶性肿瘤。这些微球通过导管注入经动脉造影和锝 99m 聚合白蛋白（Tc-MAA）计划预先治疗的肿瘤供血动脉分支。然而，目前这些微球悬浮在不透明的介质中，如 5%的葡萄糖溶液（D5）。为了监测微球实时植入肿瘤的情况，可以将 Y 微球悬浮在欧乃派克造影剂中，以便能够实时可视化微球在肿瘤内的正确分布。研究了不同浓度的欧乃派克混合 Y 微球的放射化学纯度。还研究了混合 Tc-MAA 与各种浓度标准造影剂的可行性。结果表明，将 Y 微球与欧乃派克混合的放射化学可行性是可以接受的，可在透视下实时可视化放射性栓塞。
