Dong Hongqiang, He Yuke, Fan Chen, Zhu Zhongqiang, Zhang Chunrong, Liu Xinju, Qian Kun, Tang Tao
College of Agriculture, Tarim University, Alaer 843300, China.
College of Plant Protection, Southwest University, Chongqing 400716, China.
Nanomaterials (Basel). 2022 Nov 3;12(21):3879. doi: 10.3390/nano12213879.
Based on high surface areas, adjustable porosity and microbicide activity, metal-organic frameworks (MOFs) HKUST-1 are widely used as drug release carriers for their slow degradation characteristics under slightly acidic conditions. In this work, porous HKUST-1 was reacted rapidly by cholinium salt (as the deprotonation agent and template) in an aqueous solution at room temperature. A novel antimicrobial system based on an imazalil encapsulated metal organic framework (imazalil IL-3@HKUST-1) was established. Imazalil IL-3@HKUST-1 could achieve synergism in inhibiting pathogenic fungi and bacteria. Moreover, six days after treatment, the slow and constant release of imazalil from imazalil IL@HKUST-1 exhibited better sustainability and microbicidal activity than imazalil. We believe that the method may provide a new strategy for related plant diseases caused by bacteria or fungi.
基于高比表面积、可调节的孔隙率和杀菌活性，金属有机框架材料（MOFs）HKUST-1因其在微酸性条件下的缓慢降解特性而被广泛用作药物释放载体。在这项工作中，多孔HKUST-1在室温下于水溶液中与胆碱盐（作为去质子化剂和模板）快速反应。建立了一种基于抑霉唑包封的金属有机框架材料（抑霉唑IL-3@HKUST-1）的新型抗菌体系。抑霉唑IL-3@HKUST-1在抑制致病真菌和细菌方面可实现协同作用。此外，处理六天后，抑霉唑从抑霉唑IL@HKUST-1中的缓慢持续释放表现出比抑霉唑更好的可持续性和杀菌活性。我们认为该方法可能为由细菌或真菌引起的相关植物病害提供一种新策略。
