Co-Innovation Center for Modern Production Technology of Grain Crop/Jiangsu Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou, China; College of Plant Protection, China Agricultural University, Beijing, China.
Co-Innovation Center for Modern Production Technology of Grain Crop/Jiangsu Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou, China.
Sci Total Environ. 2021 Sep 15;787:147422. doi: 10.1016/j.scitotenv.2021.147422. Epub 2021 May 1.
In this work, a pH-responsive pesticide delivery system using mesoporous silica nanoparticles (MSNs) as the porous carriers and coordination complexes of Cu ions and tannic acid (TA-Cu) as the capping agent was established for controlling pyraclostrobin (PYR) release. The results showed the loading capacity of PYR@MSNs-TA-Cu nanoparticles for pyraclostrobin was 15.7 ± 0.5% and the TA-Cu complexes deposited on the MSNs surface could protect pyraclostrobin against photodegradation effectively. The nanoparticles had excellent pH responsive release performance due to the decomposition of TA-Cu complexes under the acid condition, which showed 8.53 ± 0.37%, 82.38 ± 1.67% of the encapsulated pyraclostrobin were released at pH 7.4, pH 4.5 after 7 d respectively. The contact angle and adhesion work of PYR@MSNs-TA-Cu nanoparticles on rice foliage were 86.3° ± 2.7° and 75.8 ± 3.1 mJ/m after 360 s respectively, indicating that TA on the surface of the nanoparticles could improve deposition efficiency and adhesion ability on crop foliage. The control effect of PYR@MSNs-TA-Cu nanoparticles against Rhizoctonia solani with 400 mg/L of pyraclostrobin was 85.82% after 7 d, while that of the same concentration of pyraclostrobin EC was 53.05%. The PYR@MSNs-TA-Cu nanoparticles did not show any phytotoxicity to the growth of rice plants. Meanwhile, the acute toxicity of PYR@MSNs-TA-Cu nanoparticles to zebrafish was decreased more than 9-fold compared with that of pyraclostrobin EC. Thus, pH-responsive PYR@MSNs-TA-Cu nanoparticles have great potential for enhancing targeting and environmental safety of the active ingredient.
在这项工作中，建立了一种使用介孔硅纳米粒子（MSNs）作为多孔载体和铜离子与单宁酸（TA-Cu）的配位复合物作为封端剂的 pH 响应型农药输送系统，用于控制吡唑醚菌酯（PYR）的释放。结果表明，吡唑醚菌酯@MSNs-TA-Cu 纳米粒子的载药量为 15.7±0.5%，并且沉积在 MSNs 表面的 TA-Cu 配合物可以有效保护吡唑醚菌酯免受光降解。由于在酸性条件下 TA-Cu 配合物的分解，纳米粒子具有出色的 pH 响应释放性能，在 pH 7.4 和 pH 4.5 下分别在 7 d 后释放了 8.53±0.37%和 82.38±1.67%的包裹吡唑醚菌酯。吡唑醚菌酯@MSNs-TA-Cu 纳米粒子在水稻叶片上的接触角和粘附功分别为 86.3°±2.7°和 75.8±3.1 mJ/m 360 s 后，表明纳米粒子表面上的 TA 可以提高在作物叶片上的沉积效率和粘附能力。400mg/L 吡唑醚菌酯@MSNs-TA-Cu 纳米粒子对丝核菌的防治效果在 7 d 后为 85.82%，而相同浓度的吡唑醚菌酯 EC 的防治效果为 53.05%。吡唑醚菌酯@MSNs-TA-Cu 纳米粒子对水稻植株的生长没有表现出任何植物毒性。同时，与吡唑醚菌酯 EC 相比，吡唑醚菌酯@MSNs-TA-Cu 纳米粒子对斑马鱼的急性毒性降低了 9 倍以上。因此，pH 响应型 PYR@MSNs-TA-Cu 纳米粒子在提高活性成分的靶向性和环境安全性方面具有巨大的潜力。
