Department of Food Function and Labeling, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo 162-8363, Japan.
Department of Food Safety and Management, Showa Women's University, Tokyo 154-8533, Japan.
Nutrients. 2022 Oct 26;14(21):4509. doi: 10.3390/nu14214509.
Recently, adverse events, such as irregular vaginal bleeding and menstrual disorders, associated with the use of dietary supplements containing , have been reported in Japan. contains phytoestrogens, such as deoxymiroestrol and miroestrol. Therefore, we investigated the use of supplements that claim to have estrogen-like effects (i.e., estrogen-like supplements) in Japanese women aged from 15 to 69 years old in an online survey. The prevalence of estrogen-like supplement use was 5%, accounting for approximately 15% of the sample, including ex-users. The majority of the users were in their 40s and 50s, mainly using these supplements for the treatment of menopausal symptoms. In contrast, the younger generation mainly used them for beauty purposes, such as weight loss, mastogenic effects, and skin care. Many of them visited a clinic or took medicines for menstrual-related troubles. In all age groups, soybeans/isoflavones were the most commonly used, followed by equol and placenta. Participants in their teens and 20s also used . Among them, 16.2% had experienced adverse events, including irregular vaginal bleeding, breast swelling and pain, and heavy menstruation. In conclusion, estrogen-like supplement use is associated with adverse events; thus, it is necessary to pay attention to the use of these supplement. Furthermore, because the purpose of use differs depending on generation, caution according to each generation is necessary.
最近，在日本报道了与使用含有 的膳食补充剂相关的不良反应，如不规则阴道出血和月经紊乱。 含有植物雌激素，如去氧米古醇和米古醇。因此，我们在一项在线调查中调查了 15 至 69 岁日本女性使用声称具有雌激素样作用的补充剂（即雌激素样补充剂）的情况。雌激素样补充剂的使用率为 5%，占样本的约 15%，包括已停用者。使用者主要是 40 多岁和 50 多岁的人群，主要将这些补充剂用于治疗更年期症状。相比之下，年轻一代主要将其用于美容目的，如减肥、乳房发育作用和皮肤护理。他们中的许多人因月经相关问题就诊或服用药物。在所有年龄段中，最常使用的是大豆/异黄酮，其次是依普黄酮和胎盘。十几岁和 20 多岁的参与者也使用 。其中，16.2%的人经历过不良反应，包括不规则阴道出血、乳房肿胀和疼痛以及月经过多。总之，雌激素样补充剂的使用与不良反应有关；因此，需要注意这些补充剂的使用。此外，由于使用目的因代际而异，因此需要根据每一代进行谨慎使用。
