The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7670110, Israel.
School of Nutritional Sciences, Peres Academic Center, Rehovot 7610202, Israel.
Nutrients. 2022 Oct 28;14(21):4552. doi: 10.3390/nu14214552.
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic with increasing prevalence. Limited treatment options and poor adherence emphasize the urgent need for novel therapies for the treatment and/or prevention of NAFLD. Bioactive natural compounds found in medicinal plants are promising as novel therapeutic agents for NAFLD. a medicinal plant with several health-promoting properties, is an encouraging candidate. The current study aimed to elucidate the metabolic effects of consumption in a high-fat-diet (HFD)-induced model of NAFLD. Male C57BL/6J mice ( = 40, 7-8-week-old) were fed a HFD (60% fat) with/without 0.5 or 2.5 gr for fifteen weeks. Diet supplementation with significantly ameliorated HFD-induced weight gain. Likewise, liver and adipose tissue weights were profoundly lower in the -fed groups. Reduced liver steatosis in those groups was corroborated by histology, plasma liver enzyme levels, and lipid profile, indicating improved liver function and lipid metabolism in addition to enhanced insulin sensitivity. The addition of to an obesogeneic diet can beneficially alleviate metabolic alterations and may be a practicable strategy for the management of NAFLD.
非酒精性脂肪性肝病（NAFLD）的患病率不断增加，已成为一种流行疾病。治疗选择有限且患者顺应性差，这强调了迫切需要新型疗法来治疗和/或预防 NAFLD。从药用植物中发现的具有生物活性的天然化合物作为治疗 NAFLD 的新型治疗剂具有广阔的前景。 是一种具有多种促进健康特性的药用植物，是一种很有前途的候选药物。本研究旨在阐明 在高脂肪饮食（HFD）诱导的 NAFLD 模型中的代谢作用。雄性 C57BL/6J 小鼠（ = 40，7-8 周龄）用 HFD（60%脂肪）喂养，同时添加/不添加 0.5 或 2.5 gr 共 15 周。 的饮食补充显著改善了 HFD 诱导的体重增加。同样，喂食 的各组肝和脂肪组织重量也明显降低。组织学、血浆肝酶水平和脂质谱证实了这些组的肝脂肪变性减少，表明除了增强胰岛素敏感性外，还改善了肝功能和脂质代谢。在致肥胖饮食中添加 可以有益地减轻代谢改变，可能是管理 NAFLD 的一种可行策略。
