哈萨克斯坦骆驼中东呼吸综合征冠状病毒和戊型肝炎病毒的血清学筛查
Serological Screening for Middle East Respiratory Syndrome Coronavirus and Hepatitis E Virus in Camels in Kazakhstan.
作者信息
Karamendin Kobey, Seidalina Aigerim, Sabyrzhan Temirlan, Nuralibekov Sardor, Kasymbekov Yermukhammet, Suleimenova Symbat, Khan Elizaveta, Alikhanov Oralbek, Narsha Uldana, Erkekulova Kalya, Kydyrmanov Aidyn
机构信息
Laboratory of Viral Ecology, Department of Virology, Scientific Production Center of Microbiology and Virology, 105 Bogenbay batyr Str., Almaty A25K1G0, Kazakhstan.
Department of Veterinary Medicine, Agrarian Faculty, M. Auezov South Kazakhstan State University, 9th Corpus, 198 M.Kh. Dulati Str., Shymkent 160013, Kazakhstan.
出版信息
Pathogens. 2022 Oct 24;11(11):1224. doi: 10.3390/pathogens11111224.
After the recent Middle East Respiratory Syndrome coronavirus (MERS-CoV) pandemic in 2013, more attention has been paid to the camel as an important source of zoonotic viral infections. Almost simultaneously, in 2013, new genotypes 7 and 8 of the hepatitis E virus (HEV) were discovered in dromedary and Bactrian camels, respectively. HEV 7 was further shown to be associated with chronic viral hepatitis in a transplant recipient. In this study, serological screening for antibodies to MERS-CoV and hepatitis E virus was carried out on large camel farms in the south and west of Kazakhstan. 6.42% of the tested camels were found to be positive for antibodies to the hepatitis E virus, which indicates its circulation in local camel population. For the first time, antibodies to the hepatitis E virus were found in Bactrians, which have been little studied to date. Antibodies to MERS-CoV were not found in the camel sera.
在2013年近期中东呼吸综合征冠状病毒（MERS-CoV）大流行之后，骆驼作为人畜共患病毒感染的重要来源受到了更多关注。几乎与此同时，2013年分别在单峰驼和双峰驼中发现了戊型肝炎病毒（HEV）的新基因型7和8。HEV 7进一步被证明与一名移植受者的慢性病毒性肝炎有关。在本研究中，对哈萨克斯坦南部和西部的大型骆驼养殖场进行了针对MERS-CoV和戊型肝炎病毒抗体的血清学筛查。发现6.42%的受试骆驼戊型肝炎病毒抗体呈阳性，这表明该病毒在当地骆驼群体中传播。首次在双峰驼中发现了戊型肝炎病毒抗体，而双峰驼迄今为止研究较少。在骆驼血清中未发现MERS-CoV抗体。
Zotero 插件