Quach Huy Quang, Ovsyannikova Inna G, Grill Diane E, Warner Nathaniel D, Poland Gregory A, Kennedy Richard B
Mayo Clinic Vaccine Research Group, Division of General of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Vaccines (Basel). 2022 Nov 3;10(11):1859. doi: 10.3390/vaccines10111859.
As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20-44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.
作为一种极具传染性的病原体，高疫苗接种覆盖率和疫苗诱导免疫的持久性是控制和消除麻疹的关键因素。在此，我们评估了1393名成年人（20 - 44岁）队列中麻疹特异性抗体的血清流行率。酶联免疫吸附测定（ELISA）结果显示，37.6%的研究对象麻疹免疫球蛋白G（IgG）呈阴性，这一比例不容小觑。我们还发现研究队列的性别和年龄对IgG水平有显著影响。我们的研究结果表明，即使在疫苗接种率很高的人群中，仍有一部分个体对麻疹的免疫力可能未达到最佳状态，在未来任何麻疹疫情爆发期间都可能易感。
