Holka Justyna, Pawlak Katarzyna, Ciepiela Olga
Students Scientific Group of Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland.
Central Laboratory, Central Teaching Hospital of University Clinical Center, Warsaw, Poland.
Cent Eur J Immunol. 2019;44(4):380-383. doi: 10.5114/ceji.2019.92789. Epub 2020 Jan 20.
Measles is highly contagious, but preventable viral disease. Its outbreaks appear all over the world, and decreasing herd immunity excludes its elimination. High levels of IgG antibodies against a virus efficiently protects against infection.
To assess the seroprevalence of anti-measles IgG in the serum of patients at different age levels tested for measles IgG at our laboratory.
The study was conducted from March to June of 2019. Retrospective analysis included results for measles-specific IgG from 364 tested patients. The age of enrolled subjects ranged from four months to 101 years, with a median age of 46, and a mean age of 43 ±18. Quantification of anti-measles IgG was performed using indirect chemiluminescence immunoassays on the DiaSorin Liaison® automated analyzer.
Our results showed a seropositivity ratio of 78.02%. The lowest number of seropositive subjects was in the group of infants (0-1 years old), with a ratio of 53.85%, and the group of adults of 19-38 years old at 55.68%. The group of the oldest patients (70-101 years old) had the highest ratio of seropositive subjects (100%), while adults of 60-69 years old had a seropositivity ratio of 97.22%.
These data suggest that the group of young adults who were vaccinated with one or two doses of MMR vaccine in childhood are the most susceptible for infection, and when working in contact with other people, should be re-vaccinated for protection against measles.
麻疹是一种具有高度传染性但可预防的病毒性疾病。其疫情在全球各地出现，群体免疫力下降阻碍了其消除。高水平的针对病毒的IgG抗体能有效预防感染。
评估在我们实验室检测麻疹IgG的不同年龄水平患者血清中抗麻疹IgG的血清流行率。
该研究于2019年3月至6月进行。回顾性分析包括364例受测患者的麻疹特异性IgG结果。纳入受试者的年龄范围为4个月至101岁，中位年龄为46岁，平均年龄为43±18岁。使用DiaSorin Liaison®自动分析仪上的间接化学发光免疫分析法对抗麻疹IgG进行定量。
我们的结果显示血清阳性率为78.02%。血清阳性受试者数量最少的是婴儿组（0 - 1岁），比例为53.85%，19 - 38岁的成年组为55.68%。年龄最大的患者组（70 - 101岁）血清阳性受试者比例最高（100%），而60 - 69岁的成年组血清阳性率为97.22%。
这些数据表明，童年时期接种过一剂或两剂MMR疫苗的年轻成年人组最易感染，在与他人接触工作时，应重新接种疫苗以预防麻疹。
