State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China.
Analyst. 2022 Nov 21;147(23):5269-5273. doi: 10.1039/d2an01441f.
We successfully constructed a new class of nanoflares based on ultra-thin silica-coated gold nanoparticles (Au@SiO) with the covalent binding of nucleic acids, which demonstrated more resistance to biothiols than that exhibited in the traditional Au-S binding strategy, for imaging the target miRNA-21 with high fidelity in living cells.
我们成功构建了一类新型的基于超薄膜状二氧化硅包覆金纳米粒子（Au@SiO）的纳米耀斑，该纳米粒子通过核酸的共价键合，表现出比传统的 Au-S 结合策略更高的抗生物硫醇能力，可在活细胞中高保真性地成像靶标 miRNA-21。
