超薄二氧化硅壳保护的纳米荧光团，通过完全避免生物硫醇的干扰，实现高保真活细胞 miRNA-21 成像。
Ultra-thin silica shell-guarded nanoflares for high-fidelity live cell miRNA-21 imaging by fully avoiding the interference of biothiols.
机构信息
State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China.
出版信息
Analyst. 2022 Nov 21;147(23):5269-5273. doi: 10.1039/d2an01441f.
PMID:36367109
Abstract
We successfully constructed a new class of nanoflares based on ultra-thin silica-coated gold nanoparticles (Au@SiO) with the covalent binding of nucleic acids, which demonstrated more resistance to biothiols than that exhibited in the traditional Au-S binding strategy, for imaging the target miRNA-21 with high fidelity in living cells.
摘要
我们成功构建了一类新型的基于超薄膜状二氧化硅包覆金纳米粒子（Au@SiO）的纳米耀斑，该纳米粒子通过核酸的共价键合，表现出比传统的 Au-S 结合策略更高的抗生物硫醇能力，可在活细胞中高保真性地成像靶标 miRNA-21。
Zotero 插件